"Just make it lower" is an alternative strategy of lipid-lowering therapy with statins in Japanese patients: LDL-cholesterol: the lower, the better; is it true for Asians? (Con).
"Just make it lower" is an alternative strategy of lipid-lowering therapy with statins in Japanese patients: LDL-cholesterol: the lower, the better; is it true for Asians? (Con).
复制标题
“降得更低”是日本患者使用他汀类药物降脂治疗的另一种策略： LDL-胆固醇：越低越好；
DOI：
10.1253/circj.cj-10-0537
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
H. Ogawa
中科院分区：
文献类型：
--
作者：
T. Sakamoto;H. Ogawa
众所周知，他汀类药物可改善心血管疾病（CVD）的预后。最近在西方国家进行的他汀类药物随机对照试验（rct）显示，如果低密度脂蛋白胆固醇（LDL-C）达到较低水平，则更能避免心血管事件的发生。然而，很明显，这一证据不能无条件地外推到亚洲人身上，因为日本人和白种人在心血管疾病的绝对发病率上存在很大差异。日本心血管事件一级或二级预防的随机对照试验结果表明，与西方人群相比，我们可以从目标LDL-C相对较高的他汀类药物中获益。在这种情况下，不仅强效的他汀类药物，而且标准的他汀类药物仍然是有利的，所谓的药物的多效性就显现出来了。在这篇综述中，我们首先讨论了不同人群中绝对事件发生率的差异，然后缺乏推荐的LDL-C治疗目标的证据，特别是在日本，尽管最近在日本进行的随机对照试验中有可靠的证据表明，使用强效他汀类药物进行积极降脂治疗可以减少冠状动脉斑块体积。最后，基于最近的数据，我们提出了一个关于当前日本人群心血管疾病二级预防的新概念。
It is well known that statins improve the prognosis of cardiovascular diseases (CVD). Recent randomized control trials (RCTs) of statins conducted in Western countries revealed greater avoidance of cardiovascular events if low-density-lipoprotein cholesterol (LDL-C) reached lower levels. However, it is obvious that this evidence cannot be unconditionally extrapolated to Asians because there are great differences between Japanese and Caucasians in the absolute onset rate of CVD. Results of RCTs with Japanese for primary or secondary prevention of cardiovascular events indicate that we could benefit from statins with a relatively higher target LDL-C as compared with Western populations. In this situation, not only strong but also standard statins are still advantageous and the so-called pleiotropic effects of the drugs come to the fore. In this review, we first discuss differences in the absolute event rate in different populations, and then the lack of evidence for recommended LDL-C treatment targets, particularly in Japanese, although there is reliable evidence for reductions in plaque volume in coronary arteries from RCTs recently conducted in Japan with aggressive lipid-lowering therapy with strong statins. Finally, based on recent data, we propose a new concept regarding the secondary prevention of CVD for current Japanese populations.
登录
查看更多内容
影响因子：
24
作者：
Watanabe, K;Sugiyama, S;Ogawa, H
通讯作者：
Ogawa, H
影响因子：
24
作者：
Yasue, Hirofumi;Mizuno, Yuji;Saito, Yoshihiko
通讯作者：
Saito, Yoshihiko
影响因子：
24
作者：
Hiro, Takafumi;Kimura, Takeshi;Matsuzaki, Masunori
通讯作者：
Matsuzaki, Masunori
影响因子：
168.9
作者：
Yokoyama, Mitsuhiro;Origasa, Hideki;Shirato, Kunio
通讯作者：
Shirato, Kunio
DOI：
10.1161/atvbaha.106.128793
发表时间：
2007-06-01
影响因子：
8.7
作者：
Haramaki, Nobuya;Ikeda, Hisao;Imaizumi, Tsutomu
通讯作者：
Imaizumi, Tsutomu