Childhood vaccinations: Hidden impact of COVID-19 on children in Singapore.
Childhood vaccinations: Hidden impact of COVID-19 on children in Singapore.
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DOI：
10.1016/j.vaccine.2020.12.054
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发表时间：
2021-01-29
期刊：
影响因子：
5.5
通讯作者：
Chin HL
中科院分区：
文献类型：
--
作者：
Zhong Y;Clapham HE;Aishworiya R;Chua YX;Mathews J;Ong M;Wang J;Murugasu B;Chiang WC;Lee BW;Chin HL
尽管冠状病毒病（COVID-19）大流行对儿童健康的直接影响很低，但在许多方面存在间接影响。我们将2020年1月至4月期间新加坡三种类型医疗机构（公共初级保健诊所、医院儿科和私人儿科诊所）的儿童疫苗接种情况与基线进行比较，并计算对麻疹群体免疫力的影响。我们发现，在所有3个地点，麻疹-腮腺炎-风疹（MMR）接种率下降了25.6%至73.6%，白喉-破伤风-百日咳灭活脊髓灰质炎-嗜血杆菌流感（5合1）接种率下降了0.4%至10.3%，肺炎球菌结合疫苗（PCV）接种率下降了8.0%至67.8%。12个月至2岁儿童的群体免疫力下降到74-84%，远低于麻疹保护的95%覆盖率。这使整个社区面临麻疹流行的风险。在2019冠状病毒病大流行期间，迫切需要开展公共卫生工作，以维持常规儿童疫苗的有效覆盖率。
Although the direct health impact of Coronavirus disease (COVID-19) pandemic on child health is low, there are indirect impacts across many aspects. We compare childhood vaccine uptake in three types of healthcare facilities in Singapore - public primary care clinics, a hospital paediatric unit, and private paediatrician clinics - from January to April 2020, to baseline, and calculate the impact on herd immunity for measles. We find a 25.6% to 73.6% drop in Measles-Mumps-Rubella (MMR) uptake rates, 0.4 – 10.3% drop for Diphtheria-Tetanus-Pertussis-inactivated Polio-Haemophilus influenza (5-in-1), and 8.0–67.8% drop for Pneumococcal conjugate vaccine (PCV) across all 3 sites. Consequent herd immunity reduces to 74–84% among 12-month- to 2-year-olds, well below the 95% coverage that is protective for measles. This puts the whole community at risk for a measles epidemic. Public health efforts are urgently needed to maintain efficacious coverage for routine childhood vaccines during the COVID-19 pandemic.
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