Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.
Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.
复制标题
使用 99mTc-HM-PAO 进行单光子发射断层扫描来研究痴呆症。
DOI：
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发表时间：
1987
影响因子：
11
通讯作者：
H. Testa
中科院分区：
文献类型：
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作者：
D. Neary;J. Snowden;R. Shields;A. Burjan;B. Northen;N. Macdermott;M. Prescott;H. Testa
对临床诊断为阿尔茨海默病、非阿尔茨海默额叶痴呆和进行性核上性麻痹的患者，使用锝 - 99m六甲基丙二胺肟（99mTc HM - PAO）进行了脑单光子发射断层成像。对摄取减少的独立评估显示，大多数阿尔茨海默病组患者存在后半球异常，而其他两组患者存在选择性前半球异常。这些发现与观察到的精神障碍模式相符。该成像技术在原发性脑萎缩的鉴别诊断中具有潜在价值。
Single photon emission tomographic imaging of the brain using 99mTc HM-PAO was carried out in patients with a clinical diagnosis of Alzheimer's disease, non-Alzheimer frontal-lobe dementia, and progressive supranuclear palsy. Independent assessment of reductions in uptake revealed posterior hemisphere abnormalities in the majority of the Alzheimer group, and selective anterior hemisphere abnormalities in both other groups. The findings were consistent with observed patterns of mental impairment. The imaging technique has potential value in the differential diagnosis of primary cerebral atrophy.