An Overview of Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.
An Overview of Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.
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自噬在幽门螺杆菌感染及相关胃癌中的研究进展。
DOI：
10.3389/fcimb.2022.847716
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
幽门螺杆菌（Helicobacter pylori， H. pylori）感染在胃癌发病机制中被认为是一类致癌物。近年来，幽门螺杆菌感染与自噬之间的相互作用关系越来越受到关注。大多数研究者认为胃癌的发病机制与幽门螺杆菌感染诱导细胞形成自噬体介导的下游信号通路密切相关。自噬参与幽门螺杆菌感染，影响胃癌的发生发展。本文就幽门螺杆菌感染影响自噬的可能机制及相关胃癌信号通路的进展进行综述。
Helicobacter pylori (H. pylori) infection is considered a class I carcinogen in the pathogenesis of gastric cancer. In recent years, the interaction relationship between H. pylori infection and autophagy has attracted increasing attention. Most investigators believe that the pathogenesis of gastric cancer is closely related to the formation of an autophagosome-mediated downstream signaling pathway by H. pylori infection-induced cells. Autophagy is involved in H. pylori infection and affects the occurrence and development of gastric cancer. In this paper, the possible mechanism by which H. pylori infection affects autophagy and the progression of related gastric cancer signaling pathways are reviewed.