Structure and Functions of the Prokaryotic Elongation Factor G
Structure and Functions of the Prokaryotic Elongation Factor G
复制标题
原核延伸因子 G 的结构和功能
作者：
A. Gudkov
从核苷酸交换、GTP水解、夫西地酸的作用机制以及EF-G结构域在易位中的功能作用等方面综述了EF-G的结构和功能数据。生化数据与EF-G分子与各种配体相互作用的结构动力学相关。EF-Tu的数据也被认为是EF-G和EF-Tu共享某些结构和功能特征。
Structural and functional data on elongation factor G (EF-G) are reviewed with regard to nucleotide exchange, GTP hydrolysis, mechanism of action of fusidic acid, and functional roles of the EF-G structural domains in translocation. Biochemical data are correlated with structural dynamics of the EF-G molecule on interaction with various ligands. Data on EF-Tu are also considered, as EF-G and EF-Tu share certain structural and functional features.