Protein Modifications Pace the Circadian Oscillation of Biological Clocks
Protein Modifications Pace the Circadian Oscillation of Biological Clocks
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DOI：
10.1007/978-4-431-55561-2_16
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
H. Yoshitane;Y. Fukada
中科院分区：
文献类型：
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作者：
H. Yoshitane;Y. Fukada
在现代社会中，许多人在睡眠、心理健康和代谢状态方面存在问题，这些问题显示出日常节奏。日常节律也可以观察到心血管疾病、过敏反应和哮喘等疾病的风险。越来越多的研究报告，药物的药用效益和不良副作用都随时间发生变化。寻找这种药物给药的最佳每日时间是非常重要的，被强调为时间药理学或时间疗法。这些好处和风险的节律是基于生物钟的时钟机制，它是由所谓的时钟基因的转录-翻译负反馈回路产生的。时间测量系统绝对需要对时钟基因产物即时钟蛋白进行翻译后修饰。生物钟蛋白修饰控制生物钟的许多方面，如稳定性、细胞定位谱、转录活性和蛋白质-蛋白质相互作用。在这一章中，我们提出了一个概述，最近的分子和遗传学研究的重点是一系列的翻译后修饰的时钟蛋白。
In modern societies, many people have trouble with their sleep, mental health, and metabolic status, which show daily rhythms. The daily rhythms are also observed in the risk of diseases such as cardiovascular disease, allergic reaction, and asthma. Increasingly, studies report time-of-the-day-dependent changes in both the medicinal benefits of drugs and their undesirable side effects. Search of the best daily timing for such drug administration is very important, being emphasized as chronopharmacology or chronotherapy. These rhythms in the benefits and the risks are based on the circadian clockwork that is generated by transcriptional–translational negative feedback loops of the so-called clock genes. The time measuring system absolutely requires post-translational modifications of the clock gene products, that is, clock proteins. Clock protein modifications control many aspects of the circadian clock such as stability, cellular localization profiles, transcriptional activity, and protein–protein interactions. In this chapter, we present an overview of recent molecular and genetic studies by focusing on a series of the post-translational modifications of clock proteins.