Desorption of small ionic fragments from oligonucleotides induced by low energy carbon ions

Desorption of small ionic fragments from oligonucleotides induced by low energy carbon ions
复制标题

低能碳离子诱导寡核苷酸中小离子片段的解吸

DOI:
10.1140/epjd/e2010-00083-x
复制
发表时间:
2010
期刊:
The European Physical Journal D
影响因子:
--
通讯作者:
Ptasinska S
Ptasinska S
中科院分区:
--
文献类型:
--
作者:
Ptasinska S

文献摘要

参考文献

被引文献

相似文献

已通过实验研究了 4 keV C+ 离子诱导的包含不同碱基序列的寡核苷酸膜的降解。将寡核苷酸沉积到镀金的不锈钢基板上,并通过四极杆质谱仪分析从膜中释放的阴离子和阳离子。使用 6 × 1014ions cm-2s-1 的恒定 C+ 离子通量记录总离子解吸率随时间的变化。在低注量下,观察到小离子碎片的形成,而在注量大于 1.2 × 1018ions cm-2 的注量下,分子从基板上溅射出来。除了研究特定碱对总阳离子解吸率的影响之外,还测量了用溴取代碱对负离子解吸的影响。这些结果表明寡核苷酸膜在离子轰击过程中发生强烈降解。
The degradation of oligonucleotide films containing differing base sequences induced by 4 keV C+ions has been studied experimentally. The oligonucleotides were deposited onto a gold coated stainless steel substrate and the anions and cations released from the films were analyzed by a quadrupole mass spectrometer. The total ion desorption yield was recorded as a function of time using a constant C+ion flux of 6 × 1014ions cm-2s-1. At low fluences the formation of small ionic fragments was observed, whilst for fluences greater than 1.2 × 1018ions cm-2molecules were sputtered from the substrate. In addition to studies of the influence of a particular base to the total cation desorption yield, the effect of base substitution with bromine was measured for negative ion desorption. These results showed a strong degradation of oligonucleotide films during ion bombardment.
重离子诱导生物细胞中的 DNA 转移
DOI: 10.1016/j.radphyschem.2004.04.136
发表时间: 2004
影响因子: 2.9
作者:
T. Vilaithong;L. D. Yu;P. Apavatjrut;B. Phanchaisri;S. Sangyuenyongpipat;S. Anuntalabhochai;I. Brown
通讯作者: I. Brown
物理吸附分子的高能离子刺激解吸
DOI: 10.1021/jp0209906
发表时间: 2002
影响因子: 3.3
作者:
C. Meserole;E. Vandeweert;Z. Postawa;B. C. Haynie;N. Winograd
通讯作者: N. Winograd
DNA 中的低能离子范围
DOI: 10.1088/0031-9155/54/16/011
发表时间: 2009
影响因子: 3.5
作者:
L. D. Yu;T. Kamwanna;I. Brown
通讯作者: I. Brown
DOI: 10.1016/0042-207x(95)00247-2
发表时间: 1996
期刊: Vacuum
影响因子: 4
作者:
J. D. Segovia
通讯作者: J. D. Segovia
放射生物学的进展:DNA 和活细胞的放射增敏
DOI: 10.1016/j.susc.2008.10.049
发表时间: 2009
期刊: Surface Science
影响因子: 1.9
作者:
S. Lacombe;S. Lacombe;C. Sech;C. Sech
通讯作者: C. Sech