Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.
Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.
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DOI：
10.1016/j.ccr.2013.10.013
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发表时间：
2013-12-09
期刊：
影响因子：
50.3
通讯作者：
Drapkin R
中科院分区：
文献类型：
--
作者：
Perets R;Wyant GA;Muto KW;Bijron JG;Poole BB;Chin KT;Chen JY;Ohman AW;Stepule CD;Kwak S;Karst AM;Hirsch MS;Setlur SR;Crum CP;Dinulescu DM;Drapkin R
高级别浆液性卵巢癌在临床和治疗上都面临着巨大的挑战。虽然传统的癌变模型都集中在卵巢作为肿瘤的起始部位，最近的研究表明，可能有额外的起源卵巢外的网站，即输卵管的分泌细胞。我们的研究表明，高级别的浆液性肿瘤可以起源于输卵管分泌上皮细胞，也建立了浆液性输卵管上皮内癌作为前病变的高级别浆液性卵巢癌和腹膜癌的动物模型中的目标Brca，TP53和Pten基因。这些发现为解决临床上重要的问题提供了一种途径，这些问题对于携带BRCA1和BRCA2突变的女性的癌症预防和早期检测至关重要。
High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site, recent studies suggest that there may be additional sites of origin outside the ovary, namely the secretory cells of the fallopian tube. Our study demonstrates that high-grade serous tumors can originate in fallopian tubal secretory epithelial cells and also establishes serous tubal intraepithelial carcinoma as the precursor lesion to high-grade serous ovarian and peritoneal carcinomas in animal models targeting the Brca, Tp53, and Pten genes. These findings offer an avenue to address clinically important questions that are critical for cancer prevention and early detection in women carrying BRCA1 and BRCA2 mutations.
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影响因子：
7.3
作者：
Ahmed, Ashour Ahmed;Etemadmoghadam, Dariush;Temple, Jillian;Lynch, Andy G.;Riad, Mohamed;Sharma, Raghwa;Stewart, Colin;Fereday, Sian;Caldas, Carlos;DeFazio, Anna;Bowtell, David;Brenton, James D.
通讯作者：
Brenton, James D.
影响因子：
3.7
作者：
Clark-Knowles KV;Senterman MK;Collins O;Vanderhyden BC
通讯作者：
Vanderhyden BC
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
82.9
作者：
Dinulescu, DM;Ince, TA;Jacks, T
通讯作者：
Jacks, T
影响因子：
3.7
作者：
Clark-Knowles, Katherine V.;Garson, Kenneth;Vanderhyden, Barbara C.
通讯作者：
Vanderhyden, Barbara C.