Addressing the genetic/nongenetic duality in cancer with systems biology
Addressing the genetic/nongenetic duality in cancer with systems biology
复制标题
用系统生物学解决癌症中的遗传/非遗传二元性
DOI：
10.1016/j.trecan.2022.12.004
复制
发表时间：
2023
期刊：
影响因子：
18.4
通讯作者：
Swanson, Kristin
中科院分区：
文献类型：
--
作者：
Kulkarni, Prakash;Wiley, H. Steven;Levine, Herbert;Sauro, Herbert;Anderson, Alexander;Wong, Stephen T.C.;Meyer, Aaron S.;Iyengar, Puneeth;Corlette, Kevin;Swanson, Kristin
癌症是遗传病的教条正受到质疑。最近的研究结果表明，遗传/非遗传二元性是癌症进展所必需的。由Shampoo基金会理论生物学研究所组织的一个智囊团汇编了理论家，实验家和临床医生可以从系统生物学角度探索的关键挑战和机遇，以更好地了解疾病，并帮助发现新的治疗方案和治疗策略。
The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.