Altered autonomic activity and reactivity in depression revealed by heart-rate variability measurement during rest and task conditions
Altered autonomic activity and reactivity in depression revealed by heart-rate variability measurement during rest and task conditions
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DOI：
10.1111/pcn.12123
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发表时间：
2014-03-01
影响因子：
11.9
通讯作者：
Shinba, Toshikazu
中科院分区：
文献类型：
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作者：
Shinba, Toshikazu
目的本研究的目的是使用心率变异性（HRV）和心率（HR）测量来评估反映抑郁症唤醒功能的自主活动和反应性。方法在未接受药物治疗的抑郁症患者（n = 22）和正常受试者（n = 47）中在休息和任务执行期间（随机数生成）测量HRV和HR。在任务之前和之后测量休息活动。对心率趋势进行功率谱分析后，分别以高频成分（HF：0.15-0.4 Hz）和低频成分（LF：0.04-0.15 Hz）与HF的比值（LF/HF）作为副交感神经和交感神经活动对应的参数。结果对于抑郁受试者，HF在初始休息状态下较低，在任务状态下抑制较少，在任务状态下超过初始休息水平。任务后的休息状态。 LF/HF 在休息时较高，在任务期间增加较少，并在任务后的休息条件下保持较高水平。最初休息期间的心率较高，对任务的反应较小。结论结果表明，不仅基线活动发生了变化，而且对抑郁症行为变化的反应也发生了变化。这些改变的自主神经测量可能与扰乱的唤醒功能有关，并且可以用作诊断测量和临床评估。
AimThe aim of the present study was to assess autonomic activity and reactivity reflecting arousal functions in depression using heart-rate variability (HRV) and heart rate (HR) measurements.MethodsHRV and HR were measured in drug-naive depressed (n = 22) and normal subjects (n = 47) both at rest and during task execution (random number generation). Rest activity was measured both before and after the task. Following power spectrum analysis of the heart rate trend, the high-frequency component (HF: 0.15-0.4 Hz) and the ratio of the low-frequency component (LF: 0.04-0.15 Hz) to the HF (LF/HF) were used as the parameters corresponding to parasympathetic and sympathetic activities, respectively.ResultsFor the depressed subjects, HF was lower during the initial rest condition, was less inhibitedduring the task condition, and exceeded the initial rest level during the rest condition following the task. LF/HF was higher at rest, increased less during the task, and maintained its higher level during the rest condition after the task. HR was higher during the initial rest period and responded less to the task.ConclusionThe results indicate alteration not only of baseline activity but also of reactivity to behavioral changes in depression. These altered autonomic measures are possibly related to the disturbed arousal function and can be used as diagnostic measures and in clinical evaluation.