Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis.
Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis.
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DOI：
10.3389/fendo.2013.00109
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发表时间：
2013
影响因子：
5.2
通讯作者：
Rynditch A
中科院分区：
文献类型：
--
作者：
Gubar O;Morderer D;Tsyba L;Croisé P;Houy S;Ory S;Gasman S;Rynditch A
Intersectins（ITSNs）是一类高度保守的蛋白质家族，从线虫到哺乳动物都有同源物。在脊椎动物中，ITSN由两个基因（itsn1和itsn2）编码，它们作为支架，最初被发现是参与内吞作用的蛋白质。进一步的研究表明，ITSN1也涉及其他几个过程，包括调节胞吐，从而表明ITSN1的兴奋性细胞的胞吐和胞吞之间的耦合作用。尽管直系同源物之间的高度保守性，ITSN功能并没有得到很好的保护，因为它们在进化过程中获得了新的特性。在这篇综述中，我们将讨论ITSN1及其同源物在胞吞和胞吞中的作用，特别是在神经元和神经内分泌细胞中。
Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.