Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12).
Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12).
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DOI：
10.1080/21541248.2021.1951590
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Ramos, Joe W
中科院分区：
文献类型：
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作者：
Ghanem, Neda Z;Matter, Michelle L;Ramos, Joe W
GTPases 的 Ras 同源 (Rho) 蛋白家族（RhoA、RhoB 和 RhoC）是 Ras 超家族的成员，调节细胞迁移、增殖、极化、粘附、基因转录和细胞骨架结构等细胞过程。 Rho GTPases 充当分子开关，在 GTP 结合（活性状态）和 GDP 结合（非活性状态）形式之间循环。白血病相关 RhoGEF (LARG) 是一种鸟嘌呤核苷酸交换因子 (GEF)，可通过促进 GDP 交换为 GTP 来激活 RhoA 亚家族 GTP 酶。 LARG 对 RhoA 亚家族 GTP 酶具有选择性，是细胞迁移和侵袭的重要调节因子。在这里，我们描述了 LARG 的调节机制，以促进理解 LARG 如何介导细胞运动等功能，并为更好地针对这些功能进行治疗提供见解。
The Ras homologous (Rho) protein family of GTPases (RhoA, RhoB and RhoC) are the members of the Ras superfamily and regulate cellular processes such as cell migration, proliferation, polarization, adhesion, gene transcription and cytoskeletal structure. Rho GTPases function as molecular switches that cycle between GTP-bound (active state) and GDP-bound (inactive state) forms. Leukaemia-associated RhoGEF (LARG) is a guanine nucleotide exchange factor (GEF) that activates RhoA subfamily GTPases by promoting the exchange of GDP for GTP. LARG is selective for RhoA subfamily GTPases and is an essential regulator of cell migration and invasion. Here, we describe the mechanisms by which LARG is regulated to facilitate the understanding of how LARG mediates functions like cell motility and to provide insight for better therapeutic targeting of these functions.