Differences in cardiovascular responses to peripherally administered GABA as influenced by basal conditions and type of anaesthesia
Differences in cardiovascular responses to peripherally administered GABA as influenced by basal conditions and type of anaesthesia
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受基础条件和麻醉类型影响，心血管对外周给药 GABA 的反应存在差异
DOI：
10.1111/j.1476-5381.1986.tb10248.x
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发表时间：
1986
影响因子：
7.3
通讯作者：
A. Meli
中科院分区：
文献类型：
--
作者：
S. Giuliani;C. Maggi;A. Meli
1在巴比妥或乌拉坦麻醉的豚鼠中研究了静脉注射γ-氨基丁酸（GABA）对心血管（血压、心率、心肌收缩力）的影响。2 GABA（0.1-10 mg kg−1）对心血管参数产生短暂的“抑制”作用，在巴比妥麻醉的动物中，随后产生短暂的“兴奋”作用。与巴比妥麻醉动物相比，乌拉坦麻醉动物的静息心血管参数较高。3印防己毒素预处理（2 mg kg−1，i. v.）几乎不影响巴比妥麻醉动物中GABA产生的心血管变化。在印防己毒素预处理的动物麻醉与氨基甲酸乙酯，GABA产生了最初的抑郁症的心血管参数，随后兴奋阶段。4.在巴比妥或氨基甲酸乙酯麻醉的动物中，六烃季铵（20 mg kg−1，i.v）抑制或显著减少GABA诱导的心血管变化。5利血平预处理降低静息心血管参数。在这些动物中，无论麻醉类型如何，静脉注射GABA的作用仅为“兴奋”型。选择用巴比妥麻醉的利血平预处理的动物用于进一步的实验。6各种GABAA受体激动剂（高牛磺酸、蝇蕈醇、THIP、5-氨基戊酸）在用巴比妥麻醉的利血平预处理动物中模拟GABA的“兴奋”作用，并阻止随后给予GABA的作用。另一方面，（±）-巴氯芬（一种选择性GABAB受体激动剂）具有轻微的抑制作用，不能阻止GABA的“兴奋性”心血管效应。[7]荷包牡丹碱和印防己毒素预处理均不能阻止经利血平预处理、巴比妥麻醉的豚鼠静脉注射GABA的“兴奋性”心血管效应。8在肾上腺切除的豚鼠或静脉注射酚妥拉明加普萘洛尔的制剂中，GABA对心血管参数仅产生较小的“抑制”作用。9这些研究结果表明，GABA通过外周作用对心血管功能发挥神经调节作用，这种作用受到以下因素的影响：（a）麻醉类型（B）心血管参数的静息值（c）交感神经系统的活动程度和（d）肾上腺髓质释放的儿茶酚胺。
1 The cardiovascular (blood pressure, heart rate, cardiac contractility) effects of i.v. γ‐aminobutyric acid (GABA) were investigated in guinea‐pigs anaesthetized with barbitone or urethane. 2 GABA (0.1–10 mg kg−1) produced a transient ‘depressive’ effect on cardiovascular parameters which in barbitone‐anaesthetized animals was followed by a transient ‘excitatory’ effect. Resting cardiovascular parameters were higher in urethane‐ as compared to barbitone‐ anaesthetized animals. 3 Picrotoxin pretreatment (2 mg kg−1, i.v.) barely affected the cardiovascular changes produced by GABA in barbitone‐anaesthetized animals. In picrotoxin pretreated animals anaesthetized with urethane, GABA produced an initial depression of cardiovascular parameters followed by an excitatory phase. 4 Hexamethonium (20 mg kg−1, i.v) suppressed or reduced markedly the GABA‐induced cardiovascular changes both in barbitone‐ or urethane‐ anaesthetized animals. 5 Reserpine pretreatment lowered resting cardiovascular parameters. In these animals, regardless of type of anaesthesia, the effects of i.v. GABA were of the ‘excitatory’ type only. Reserpine pretreated animals anaesthetized with barbitone were selected for further experiments. 6 Various GABAA receptor agonists (homotaurine, muscimol, THIP, 5‐aminovaleric acid) mimicked the ‘excitatory’ effect of GABA in reserpine pretreated animals anaesthetized with barbitone and prevented the effects of subsequent GABA administration. On the other hand (±)‐baclofen, a selective GABAB receptor agonist, had a slight depressant effect and did not prevent the ‘excitatory’ cardiovascular effects of GABA. 7 Neither bicuculline nor picrotoxin pretreatment prevented the ‘excitatory’ cardiovascular effect of i.v. GABA in reserpine pretreated, guinea‐pigs anaesthetized with barbitone. 8 In adrenalectomized guinea‐pigs or in preparations receiving i.v. phentolamine plus propranolol, GABA produced only a small ‘depressant’ effect on cardiovascular parameters. 9 These findings demonstrate that GABA exerts a neuromodulatory effect on cardiovascular function via peripheral actions which is influenced by: (a) type of anaesthesia (b) resting values of cardiovascular parameters (c) degree of activity of the sympathetic nervous system and (d) catecholamine release from the adrenal medulla.