One degree of freedom for dominance in indirect association studies
One degree of freedom for dominance in indirect association studies
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DOI：
10.1002/gepi.20207
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Clayton, David
中科院分区：
文献类型：
--
作者：
Chapman, Juliet;Clayton, David
使用标签单核苷酸多态性（SNP）的关联性检验假设致病基因座的等位基因起相加作用，然后通过一组标签SNP间接预测这些等位基因。在存在强显性效应的情况下，该模型是不正确的，并且需要包括额外的项，其使用标签SNP来预测因果基因座的杂合性。假设这种情况下，一个强大的优势效应，我们提出了一个适当的检验统计量，并调查有多少权力，如果有的话，我们增加了这个单一的自由度的优势。
Usual tests of association using tag single nucleotide polymorphisms (SNPs) assume that the alleles of the causal locus act additively and that these alleles are then predicted indirectly via a set of tag SNPs. In the presence of strong dominance effects this model is not correct and an extra term needs to be included, which uses the tag SNPs to predict the heterozygosity of the causal locus. Assuming this scenario of a strong dominance effect, we present an appropriate test statistic and investigate how much power, if any, we gain by adding this single degree of freedom for dominance.