Nanostructuring carbon fibre probes for use in central venous catheters.
Nanostructuring carbon fibre probes for use in central venous catheters.
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DOI：
10.1016/j.aca.2013.11.013
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发表时间：
2014-02
影响因子：
6.2
通讯作者：
Meixian Li;J. Phair;M. Cardosi;James Davis
中科院分区：
文献类型：
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作者：
Meixian Li;J. Phair;M. Cardosi;James Davis
本发明描述了一种碳纤维探针，其利用内源性生物标志物的氧化来提供关于血管内接入线路的状况的诊断信息。通过阳极氧化对探针表面进行改性，以提供对尿酸盐的高选择性，尿酸盐用作氧化还原探针，通过该氧化还原探针可以确定pH。获得了能斯特响应（-60 mV/pH），其不受生物流体中常见的其他氧化还原物种的干扰。的探针的电分析性能进行了优化，并通过测试全血中的响应证明了该方法的适用性。
A carbon fibre probe is described which utilises the oxidation of an endogenous biomarker to provide diagnostic information on the condition of intravascular access lines. The probe surface was modified through anodic oxidation to provide a high selectivity towards urate which was used as a redox probe through which the pH could be determined. A Nernstian response (−60 mV/pH) was obtained which was free from the interference of other redox species common to biofluids. The electroanalytical performance of the probe has been optimised and the applicability of the approach demonstrated through testing the responses in whole blood.