Nickel-catalyzed intermolecular [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes
Nickel-catalyzed intermolecular [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes
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DOI：
10.1021/ja0494306
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发表时间：
2004-09-01
影响因子：
15
通讯作者：
Komagawa, S
中科院分区：
文献类型：
--
作者：
Saito, S;Masuda, M;Komagawa, S
在 10 mol%“Ni(PPh3)2”（由 Ni(cod)2 和 PPh3 原位制备）存在下，环丙叉基乙酸乙酯 (1a) 和末端炔烃 (2) 的 [3 + 2 + 2] 共环化反应顺利进行。由于引入吸电子基团而引起的1a的高反应活性对于该反应的进展非常重要。以高选择性的方式合成了环庚二烯衍生物，收率良好。
The [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate (1a) and terminal alkynes (2) proceeded smoothly in the presence of 10 mol % “Ni(PPh3)2”, which was prepared in situ from Ni(cod)2and PPh3. The high reactivity of1a, which was induced by the introduction of an electron-withdrawing group, is very important for the progress of this reaction. The cycloheptadiene derivatives were synthesized in highly selective manner in good yields.