Forty-eight-hour polysomnographic evaluation of narcolepsy.
Forty-eight-hour polysomnographic evaluation of narcolepsy.
复制标题
发作性睡病的四十八小时多导睡眠图评估。
作者：
Browman,CP;Gujavarty,KS;Yolles,SF;Mitler,MM
11名发作性睡症患者和11名对照组受试者分别完成了5项多次睡眠潜伏期测试（MSLT）和5项清醒维持测试（MWT），分别要求受试者在仰卧状态下“入睡”和在舒适坐姿下“保持清醒”。在白天的两项测试中，发作性睡症受试者的睡眠潜伏期都比对照组短，睡眠开始的快速眼动期（SOREMPs）频率更高。每组在MWT上的睡眠潜伏期都比MSLT长。对于嗜睡症患者，两种日间测试的差异表明，测试测量的是睡眠-觉醒倾向的不同方面。发作性嗜睡者在MSLT上的睡眠潜伏期与MWT上的睡眠潜伏期无关。此外，发作性睡症受试者在MSLT期间的soremp数量与MWT期间的soremp数量无关。发作性睡症受试者夜间快速眼动睡眠的测量与MSLT上的睡眠潜伏期相关。特别是，夜间的快速眼动潜伏期可以高度预测嗜睡症患者的嗜睡程度。夜间睡眠潜伏期往往与对照组白天测试的睡眠潜伏期有关。在两个晚上的研究中，发作性睡病患者的睡眠潜伏期较短，觉醒频率较高，快速眼动潜伏期较短。
Eleven narcoleptic and 11 control subjects completed five multiple sleep latency test (MSLT) procedures with instructions to “fall asleep” while supine and five maintenance of wakefulness test (MWT) procedures with instructions to “remain awake” while comfortably sitting. Narcoleptic subjects had a shorter sleep latency and a higher frequency of sleep onset REM periods (SOREMPs) on both daytime tests than controls. Each group had a longer sleep latency on the MWT than MSLT. For patients with narcolepsy, the differences between the two daytime procedures suggest the tests measure distinct aspects of sleep-wake tendency. Sleep latency on the MSLT did not correlate with sleep latency on the MWT for narcoleptic subjects. Furthermore, the number of SOREMPs during the MSLT for narcoleptic subjects did not correlate with the number of SOREMPs during the MWT. Measures of nocturnal REM sleep for narcoleptic subjects correlated with sleep latency on the MSLT. In particular, REM latency at night was highly predictive of the magnitude of hypersomnia for patients with narcolepsy. Sleep latency at night tended to relate to sleep latency on the daytime tests for controls. Patients with narcolepsy had a shorter sleep latency, more frequent arousals, and a shorter REM latency than control subjects across the 2 nights of study.