Targeting the CCL2-CCR2 axis in depressive disorders.
Targeting the CCL2-CCR2 axis in depressive disorders.
复制标题
靶向CCL2-CCR2轴在抑郁症中的作用
DOI：
10.1007/s43440-021-00280-w
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Leśkiewicz M
中科院分区：
文献类型：
--
作者：
Curzytek K;Leśkiewicz M
由于情感障碍被认为是免疫系统功能障碍的基础，在其病理生理学中的重要作用被分配给促炎介质。近年来，趋化因子（chemokines）作为一组趋化性细胞因子，在脑疾病的发展和治疗中已成为基础和临床科学家关注的焦点。其中，趋化因子CCL 2及其主要受体CCR 2已成为抑郁症脑-免疫系统对话异常的候选介质。除了趋化活性之外，CCL 2-CCR 2轴还参与各种神经生物学过程，神经发生、神经传递、神经炎症、神经变性以及神经再生。鉴于CCL 2-CCR 2对可以对神经系统施加的免疫调节可能性的范围，其促炎特性最初被认为是抑郁症发展的主要贡献者。然而，进一步的研究表明，神经系统的功能障碍与由CCL 2-CCR 2二分体功能障碍所表现的受损的稳态特性相当相关。本文综述了近年来有关生理和病理条件下CCL 2-CCR 2轴在中枢神经系统中作用的文献资料，以及该配体-受体系统对情感性精神障碍发病过程的贡献。此外，这篇文章提请注意CCL 2-CRR 2通路作为具有抗抑郁潜力的潜在药理学靶点的重要性。
Since affective disorders are considered to be underlain by the immune system malfunction, an important role in their pathophysiology is assigned to the proinflammatory mediators. Recently, chemokines, the group of chemotactic cytokines, have become a focus for basic and clinical scientists in the context of the development and treatment of brain diseases. Among them, chemokine CCL2 and its main receptor CCR2 have become candidate mediators of abnormal brain-immune system dialogue in depression. Besides the chemotactic activity, the CCL2-CCR2 axis is involved in various neurobiological processes, neurogenesis, neurotransmission, neuroinflammation, neurodegeneration, as well as neuroregeneration. Given the range of immunomodulatory possibilities that the CCL2-CCR2 pair can exert on the nervous system, its proinflammatory properties were initially thought to be a major contributor to the development of depressive disorders. However, further research suggests that the malfunctions of the nervous system are rather associated with impaired homeostatic properties manifested by the CCL2-CCR2 dyad dysfunctions. This review aims to present literature data on the action of the CCL2-CCR2 axis in the central nervous system under physiological and pathological conditions, as well as the contribution of this ligand-receptor system to the processes underlying affective disorders. Additionally, this article draws attention to the importance of the CCL2-CRR2 pathway as a potential pharmacological target with antidepressant potential.
登录
查看更多内容
炎症激活与忧郁症主要抑郁症的住院患者的单核细胞中糖皮质激素受体α/β表达比降低有关。
影响因子：
6.8
作者：
Carvalho LA;Bergink V;Sumaski L;Wijkhuijs J;Hoogendijk WJ;Birkenhager TK;Drexhage HA
通讯作者：
Drexhage HA
影响因子：
3.7
作者：
Girotti, Milena;Donegan, Jennifer J.;Morilak, David A.
通讯作者：
Morilak, David A.
影响因子：
6.8
作者：
Chen, Helen J.;Antonson, Adrienne M.;Gur, Tamar L.
通讯作者：
Gur, Tamar L.
影响因子：
4.7
作者：
Banisadr, G;Quéraud-Lesaux, F;Parsadaniantz, SM
通讯作者：
Parsadaniantz, SM
影响因子：
3.7
作者：
Edman, Linda C.;Mira, Helena;Arenas, Ernest
通讯作者：
Arenas, Ernest