CLINICAL AND LABORATORY EVIDENCE OF AUTOIMMUNITY IN ACUTE SCHIZOPHRENIA
CLINICAL AND LABORATORY EVIDENCE OF AUTOIMMUNITY IN ACUTE SCHIZOPHRENIA
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DOI：
10.1111/j.1749-6632.1987.tb35829.x
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发表时间：
1987-05-28
影响因子：
5.2
通讯作者：
RAGU, U
中科院分区：
文献类型：
--
作者：
GANGULI, R;RABIN, BS;RAGU, U
对28例临床明确诊断的精神分裂症患者进行了免疫功能测定。我们的数据提供的实验室证据表明，精神分裂症患者具有与自身免疫过程一致的特征，针对大脑的成分，可能参与精神分裂症的发病机制或病因。三分之一的患者有临床上明显的自身免疫综合征，与他们的精神疾病无关。在9名自身免疫性疾病患者中，2名患者血清中有一种自身抗体，5名患者血清中有一种以上的自身抗体。18例无自身免疫性疾病临床证据的患者中有12例未检测到自身抗体。与对照组相比，患者人群对PHA和PWM的促有丝分裂反应显著降低。50%的患者血液中HLA-DR（+）OKT 4（+）辅助性T淋巴细胞百分比增加（大于5%）。通过测量淋巴细胞向额叶盐水提取物的转化，以及通过从额叶、扣带回、室间隔和海马提取的抗原的免疫印迹，来寻求对脑抗原的免疫反应性。淋巴细胞转化没有显示患者和对照组之间的差异。发现正常血清含有对这些脑抗原中的一些的抗体。然而，精神分裂症患者有抗体的抗原，海马，隔区和扣带回，没有遇到正常血清分析。
A number of assays were performed to assess immunologic function in 28 patients with clinically well-defined schizophrenia. Our data provide laboratory evidence that patients with schizophrenia have characteristics consistent with an autoimmune process, directed to components of the brain, which may participate in either the pathogenesis or etiology of schizophrenia. One-third of our patients had a clinically evident autoimmune syndrome unrelated to their psychiatric illness. Of the nine patients with an autoimmune disease, two had one autoantibody in their serum and five had more than one autoantibodies. Twelve of eighteen patients without clinical evidence of autoimmune disease had no detectable autoantibodies. Mitogenic responses to PHA and PWM were significantly reduced in the patient population when compared to controls. Fifty percent of the patients had an increased percentage (greater than 5%) of blood-borne HLA-DR (+) OKT4 (+) T-helper lymphocytes. Immune reactivity toward brain antigens was sought by measuring lymphocyte transformation to a saline extract of frontal lobe, and by immunoblotting of antigens extracted from frontal lobe, cingulate gyrus, interventricular septum, and hippocampus. Lymphocyte transformation did not reveal differences between patient and control groups. Normal sera were found to contain antibody to some of these brain antigens. However, patients with schizophrenia had antibody to antigens of the hippocampus, septal region and cingulate gyrus which were not encountered during analysis of normal sera.