Prospective study of adolescent alcohol consumption and risk of benign breast disease in young women.
Prospective study of adolescent alcohol consumption and risk of benign breast disease in young women.
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DOI：
10.1542/peds.2009-2347
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发表时间：
2010-05
期刊：
影响因子：
8
通讯作者：
Colditz GA
中科院分区：
文献类型：
--
作者：
Berkey CS;Willett WC;Frazier AL;Rosner B;Tamimi RM;Rockett HR;Colditz GA
使用真实的时间收集的酒精饮料消费数据，前瞻性地调查青少年饮酒与年轻女性活检证实的良性乳腺疾病（BBD）风险之间的关系。《今日成长研究》（Growing Up Today Study，简称GUTS）是一项针对美国9至15岁女性的前瞻性队列研究，从1996年到2001年每年进行一次问卷调查，随后在2003年、2005年和2007年进行问卷调查。在2003年的调查中，参与者（当时年龄在16至23岁之间）提供了他们过去一年酒精饮料消费的信息。在2005年和2007年的调查中，共有6899名女性（年龄在18至27岁之间）报告了医疗保健提供者是否曾诊断出她们患有BBD（n=147例）以及是否通过活检确诊（n=67例）; 6752名女性报告从未被诊断出患有BBD。校正年龄和BMI后，饮酒量与活检证实的BBD风险增加相关（OR=1.50/饮/天，95%CI：1.19，1.90）。与从不饮酒或每周饮酒少于一次的女性相比，通常每周饮酒6或7天的女性风险更高（OR=5.50，95%CI：1.23，24.53）。在青春期饮用酒精饮料的量更大，更频繁，可能会增加年轻女性BBD的发生率。建议青少年避免酒精饮料，沿着吸烟和阳光照射，可能会降低成年后的癌症发病率。
To investigate prospectively, using alcoholic beverage consumption data collected in real time, the association between adolescent drinking and risk of biopsy-confirmed benign breast disease (BBD) in young women. The Growing Up Today Study (GUTS) is a prospective cohort study of U.S. females, aged 9 to 15 years at baseline, with annual questionnaires from 1996 through 2001, followed by questionnaires in 2003, 2005 and 2007. On the 2003 survey, the participants (then aged 16 to 23 years) provided information about their past-year alcoholic beverage consumption. On the 2005 and 2007 surveys, a total of 6899 females (aged 18 to 27 years) reported whether a health care provider had ever diagnosed them with BBD (n=147 cases) and whether it was confirmed by biopsy (n=67 cases); 6752 females reported never being diagnosed with BBD. Adjusted for age and BMI, quantity of alcohol consumed was associated with increased risk of biopsy-confirmed BBD (OR=1.50 per drink/day, 95%CI: 1.19, 1.90). Females who typically drank six or seven days a week were at higher risk (OR=5.50, 95%CI: 1.23, 24.53) compared to those who never drank or who drank less than once per week. Higher amounts consumed, and more frequent consumption, of alcoholic beverages in adolescence may increase the occurrence of BBD in young women. Advising teens to avoid alcoholic beverages, along with smoking and sun exposure, may reduce cancer incidence in adulthood.