F-actin-binding proteins
F-actin-binding proteins
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DOI：
10.1016/s0959-440x(98)80034-1
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发表时间：
1998-04-01
影响因子：
6.8
通讯作者：
McGough, A
中科院分区：
文献类型：
--
作者：
McGough, A
The study of proteins that bind filamentous actin (F-actin) is entering an exciting stage as more and more structures are determined. After more than 50 years in which the focus was on muscle proteins, emphasis has recently shifted towards understanding the complex interplay among actin-binding molecules in non-muscle cells. To date, the binding sites for eight classes of filament-binding molecules have been determined by combining low-to intermediate-resolution maps obtained by electron microscopy with atomic structures determined by X-ray crystallography and NMR. Recent results have dramatically accentuated the importance of filament geometry and actin conformation in defining these interactions.
