Piezo2 is the principal mechanotransduction channel for proprioception.
Piezo2 is the principal mechanotransduction channel for proprioception.
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DOI：
10.1038/nn.4162
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发表时间：
2015-12
影响因子：
25
通讯作者：
Patapoutian A
中科院分区：
文献类型：
--
作者：
Woo SH;Lukacs V;de Nooij JC;Zaytseva D;Criddle CR;Francisco A;Jessell TM;Wilkinson KA;Patapoutian A
本体感觉是对身体和肢体位置的感知，由本体感受器介导，本体感受器是一种专门的机械感觉神经元，可以传递肌肉、肌腱、皮肤和关节所经历的拉伸和紧张的信息。在哺乳动物中，介导本体感觉的拉伸敏感通道的分子身份尚不清楚。在这里，我们表明机械激活（MA）非选择性阳离子通道Piezo2在支配肌肉纺锤体和高尔基肌腱器官的小鼠本体感受器的感觉末梢表达。缺乏Piezo2本体感觉神经元的两个独立小鼠系表现出严重的身体运动不协调和肢体位置异常。此外，主要标记本体感受器的Pvalb+神经元的机械敏感性在体外依赖于Piezo2，并且在Piezo2缺陷小鼠中，肌肉神经记录中本体感受器的拉伸诱导放电显着减少。总之，我们的研究结果表明，Piezo2是哺乳动物本体感受器的主要机械传感器。
Proprioception, the perception of body and limb position, is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the stretch and tension experienced by muscles, tendons, skin, and joints. In mammals, the molecular identity of the stretch-sensitive channel that mediates proprioception is unknown. Here we show that the mechanically activated (MA) nonselective cation channel Piezo2 is expressed in sensory endings of proprioceptors innervating muscle spindles and Golgi tendon organs in mice. Two independent mouse lines that lack Piezo2 in proprioceptive neurons show severely uncoordinated body movements and abnormal limb positions. Moreover, the mechanosensitivity of Pvalb+ neurons that predominantly mark proprioceptors are dependent on Piezo2 in vitro, and the stretch-induced firing of proprioceptors in muscle-nerve recordings is dramatically reduced in Piezo2-deficient mice. Together, our results indicate that Piezo2 is the major mechanotransducer of mammalian proprioceptors.