The innate host response in caries and periodontitis
The innate host response in caries and periodontitis
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DOI：
10.1111/jcpe.12781
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发表时间：
2017-12-01
影响因子：
6.7
通讯作者：
Herzberg, Mark
中科院分区：
文献类型：
--
作者：
Meyle, Joerg;Dommisch, Henrik;Herzberg, Mark
天然免疫能迅速保护宿主免受感染性损伤。这些反应具有有限的特异性和耗尽性，不能提供长期保护。功能性体液和效应分子有助于抵抗感染因子，驱动免疫反应，并指导细胞players.AimTo回顾文献和目前的知识总结有关组织的功能，与龋齿和牙周炎相关的先天免疫的细胞因子和可溶性介质。回顾科学journals.ResultsThe先天免疫反应是至关重要的抵抗龋齿和牙周炎，并迅速试图保护免受感染剂在牙齿硬组织和软组织。可溶性介质包括专门的蛋白质和脂质。它们的功能是向免疫和炎症细胞发出信号，提供抗微生物药物抗性，并诱导潜在的受损tissues.ConclusionsFar低于适应性免疫研究机制，先天免疫反应是一个新兴的科学和治疗前沿。先天性应答的可溶性介质提供信号网络以组织对感染的近即时分子和细胞应答，包括直接和即时的抗微生物活性。通常需要在人类疾病和动物模型中进行进一步的研究。
IntroductionInnate immunity rapidly defends the host against infectious insults. These reactions are of limited specificity and exhaust without providing long-term protection. Functional fluids and effector molecules contribute to the defence against infectious agents, drive the immune response, and direct the cellular players.AimTo review the literature and present a summary of current knowledge about the function of tissues, cellular players and soluble mediators of innate immunity relevant to caries and periodontitis.MethodsHistorical and recent literature was critically reviewed based on publications in peer-reviewed scientific journals.ResultsThe innate immune response is vital to resistance against caries and periodontitis and rapidly attempts to protect against infectious agents in the dental hard and soft tissues. Soluble mediators include specialized proteins and lipids. They function to signal to immune and inflammatory cells, provide antimicrobial resistance, and also induce mechanisms for potential repair of damaged tissues.ConclusionsFar less investigated than adaptive immunity, innate immune responses are an emerging scientific and therapeutic frontier. Soluble mediators of the innate response provide a network of signals to organize the near immediate molecular and cellular response to infection, including direct and immediate antimicrobial activity. Further studies in human disease and animal models are generally needed.