Effect of sugar-sweetened beverages on body weight in children: design and baseline characteristics of the Double-blind, Randomized INtervention study in Kids
Effect of sugar-sweetened beverages on body weight in children: design and baseline characteristics of the Double-blind, Randomized INtervention study in Kids
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DOI：
10.1016/j.cct.2011.10.007
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发表时间：
2012-01-01
影响因子：
2.2
通讯作者：
Katan, Martijn Bernard
中科院分区：
文献类型：
--
作者：
de Ruyter, Janne Catharine;Olthof, Margreet Renate;Katan, Martijn Bernard
背景：在观察性研究中，含糖饮料的摄入与超重有关。一个可能的解释是，液体糖不会使人饱足，它们的摄入量不能通过减少其他食物的热量摄入来补偿。然而，由于先前的研究未设盲，因此该假设的干预研究证据不确定。因此，结果可能会受到影响的期望和行为线索，而不是由physiologicalmechanism.Methods：我们设计的双盲，随机干预儿童研究（DRINK）检查体重的影响，隐蔽地取代无糖饮料加糖。只有经常喝含糖饮料的儿童才有资格参加。我们招募了642名健康儿童（平均年龄8.2岁，范围4.8-11.9岁）。我们设计、测试和生产了含10%糖的定制饮料和具有相同甜味和外观的无糖饮料。儿童每天接受一罐250毫升的学习饮料，持续18个月。我们在0、6、12和18个月时进行身体测量。主要结局是年龄BMI的z评分。两组之间该评分的最大预测差异为0.72，对应于2.3 kg的体重差异。讨论：双盲设计消除了影响体重的行为因素。如果儿童在饮用无糖饮料时比饮用含糖饮料时获得更少的身体脂肪，这将表明液体糖确实绕过了生物饱足机制。这也表明，减少液体糖可以比减少其他卡路里来源更有效地减少体脂。(C)2011 Elsevier Inc. All rights reserved.
Background: Intake of sugar-sweetened beverages is associated with overweight in observational studies. A possible explanation is that liquid sugars do not satiate and that their intake is not compensated by reduced caloric intake from other foods. However, evidence from intervention studies for this hypothesis is inconclusive because previous studies were not blinded. Hence results may have been influenced by expectations and behavioral cues rather than by physiological mechanisms.Methods: We designed the Double-blind, Randomized INtervention study in Kids (DRINK) to examine the effect on body weight of covertly replacing sugar-sweetened by sugar-free beverages. Children were only eligible if they habitually drank sugar-sweetened beverages. We recruited 642 healthy children (mean age 8.2, range 4.8-11.9). We designed, tested and produced custom-made beverages containing 10% sugar and sugar-free beverages with the same sweet taste and look. Children receive one 250 mL can of study beverage daily for 18 months. We perform body measurements at 0, 6, 12 and 18 months. The primary outcome is the z-score of BMI for age. The maximum predicted difference in this score between groups is 0.72, which corresponds with a difference in body weight of 2.3 kg.Discussion: The double-blind design eliminates behavioral factors that affect body weight. If children gain less body fat when drinking sugar-free than when drinking sugar-sweetened beverages that would show that liquid sugar indeed bypasses biological satiation mechanisms. It would also suggest that a reduction in liquid sugars could decrease body fat more effectively than reduction of other calorie sources. (C) 2011 Elsevier Inc. All rights reserved.