High altitude adaptation of the schizothoracine fishes (Cyprinidae) revealed by the mitochondrial genome analyses
High altitude adaptation of the schizothoracine fishes (Cyprinidae) revealed by the mitochondrial genome analyses
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线粒体基因组分析揭示裂腹鱼类（鲤科）的高海拔适应
DOI：
10.1016/j.gene.2012.12.096
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发表时间：
2013-04-01
期刊：
影响因子：
3.5
通讯作者：
Zhong, Yang
中科院分区：
文献类型：
--
作者：
Li, Yali;Ren, Zhumei;Zhong, Yang
裂胸科鱼类，又称“山鲤”，广泛分布于青藏高原及其周边地区。尽管它们提供了高海拔适应的主要例子，但这些鲤鱼谱系之间的系统发育关系和分化时间仍然存在争议。此外，对高海拔适应的遗传基础也知之甚少。在这项研究中，我们确定了两种裂胸科鱼类的线粒体基因组，分别代表“形态原始”进化枝和“形态特化”进化枝。在整个鲤形目的进化框架内估计了系统发育树和分化时间。我们的研究结果表明，裂胸科鱼类具有多进化关系，并提出了两次独立的迁徙事件：一次是晚中新世的“形态原始”进化枝，另一次是始新世的“形态特化”进化枝。晚中新世至上新世各分支的快速物种形成事件与青藏高原地质加速的时间相对应。有趣的是，我们在“形态特化”进化支的线粒体基因组中发现了积极选择作用于蛋白质编码基因的证据，这意味着这种鲤形鱼类衍生谱系的高海拔适应可能存在遗传基础。(C) 2013 Elsevier B.V.版权所有
The schizothoracine fishes, also known as "mountain carps" are widely distributed in the Qinghai-Tibetan Plateau and its peripheral regions. Although they provide a prime example of high altitude adaptation, the phylogenetic relationships and the divergence times among these carp lineages are still controversial. Moreover, the genetic basis for high altitude adaptation is also poorly understood. In this study, we determined the mitochondrial genomes from two species of the schizothoracine fishes, representing a "morphologically primitive" clade and "morphologically specialized" clade, respectively. The phylogenetic tree and the divergence times were estimated within the evolutionary framework of the entire order Cypriniformes. Our results indicate a polyphylyetic relationship of the schizothoracine fishes and suggest two independent migration events into the Qinghai-Tibetan Plateau: one by the "morphologically primitive" clade in the Late Miocene and another by the "morphologically specialized" clade in the Eocene. Rapid speciation evenrs of each clade from the Late Miocene to the Pliocene correspond to the timing of the geologic acceleration of the Qinghai-Tibetan Plateau. Interestingly, we found evidence for positive selection acting on the protein coding genes in the mitochondrial genomes of the "morphologically specialized" clade, implying a possible genetic basis for high altitude adaptation in this derived lineage of cypriniform fishes. (C) 2013 Elsevier B.V. All rights reserved.