Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio)
Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio)
复制标题
活性氧参与斑马鱼（斑马鱼）代偿性生长期间的肝功能恢复
DOI：
10.1016/j.bbrc.2018.03.149
复制
发表时间：
2018-05-05
影响因子：
3.1
通讯作者：
Li, Wensheng
中科院分区：
文献类型：
--
作者：
Jia, Jirong;Zhang, Yazhou;Li, Wensheng
补偿性生长是指当不利环境得到改善时，伴随着代谢调节的加速生长阶段。在这里，我们报告，肝脏氧化磷酸化（OXPHOS）活性增强在斑马鱼的补偿生长。线粒体！代谢使得能够产生活性氧（ROS），其激活nrf 2（核因子-红细胞2相关因子2）信号传导途径以及mTOR信号传导途径。Tempol（一种超氧化物歧化酶模拟物）处理阻断了斑马鱼肝脏中的ROS信号传导以及CG。这些结果表明，线粒体活性氧信号是必不可少的补偿生长的发生在斑马鱼。(C)2018爱思唯尔公司All rights reserved.
Compensatory growth (CG) is defined as a phase of accelerated growth when the disadvantageous environment is improved, accompanied by metabolic adjustment. Here, we report that hepatic oxidative phosphorylation (OXPHOS) activity was enhanced during compensatory growth in zebrafish. Mitochondria! metabolism enabled the generation of reactive oxygen species (ROS), which activated the nrf2 (nuclear factor-erythroid 2-related factor 2) signaling pathway, as well as the mTOR signaling pathway. Tempol (a superoxide dismutase mimetic) treatment blocked ROS signaling in the liver as well as CG in zebrafish. These results demonstrated that mitochondrial ROS signaling are essential for the occurrence of compensatory growth in zebrafish. (C) 2018 Elsevier Inc. All rights reserved.