Non-verbal semantic impairment in semantic dementia
Non-verbal semantic impairment in semantic dementia
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DOI：
10.1016/s0028-3932(00)00034-8
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Hodges, JR
中科院分区：
文献类型：
--
作者：
Bozeat, S;Ralph, MAL;Hodges, JR
语义性痴呆患者的临床表现主要是贫血和语言理解能力差。尽管许多研究人员认为这些患者对非语言和语言刺激的理解能力均受损，但语义恶化的证据主要来自包括某种形式的语言输入或输出的任务。很少有研究完全使用非语言评估来调查语义障碍，少数例外是基于单个病例的结果（[3]：Breedin SD、Saffran EM、Coslett HE。语义痴呆患者具体效应的逆转。Cognitive Neuropsychology 1994,11:617-660，[12]：Graham KS、Becker JT、Patterson K、Hodges JR。失语：原发性进行性失语症案例？见：Parkin A，记忆神经心理学案例研究，劳伦斯·埃尔鲍姆，1997 年。第 83-110 页，[21]。Lambon Ralph MA，Howard D. Gogi 失语症或语义痴呆？模拟和评估进行性流畅认知失语症的语言理解能力。神经心理学，（正在出版）。这项研究采用声音识别和语义关联任务来调查 10 名语义性痴呆患者的语言和非语言理解缺陷的性质，这些患者在评估的语言和非语言条件下均受到损害，他们在这些任务上的准确性与他们在一系列需要访问语义记忆的其他测试中的分数直接相关，进一步的分析表明，表现是根据概念和声音熟悉程度进行评分的，此外，还确定了不同条件下的显着项目一致性。这些结果支持这样一种观点，即患者在所有模态中的缺陷都是由于单一的、中心的概念知识网络中的退化造成的。事实证明，声音-图像匹配任务对语义障碍更敏感，并且患者在语义关联测试中的图像表现明显优于单词版本。我们认为，这些差异直接源于输入模态和语义记忆之间的映射性质。从一定程度的系统性和有关对象的概念性知识。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
The clinical presentation of patients with semantic dementia is dominated by anemia and poor verbal comprehension. Although a number of researchers have argued that these patients have impaired comprehension of non-verbal as well as verbal stimuli, the evidence for semantic deterioration is mainly derived from tasks that include some form of verbal input or output. Few studies have investigated semantic impairment using entirely non-verbal assessments and the few exceptions have been based on results from single cases ([3]: Breedin SD, Saffran EM, Coslett HE. Reversal of the concreteness effect in a patient with semantic dementia. Cognitive Neuropsychology 1994,11:617-660, [12]: Graham KS, Becker JT, Patterson K, Hodges JR. Lost for words: a case of primary progressive aphasia? In: Parkin A, editor. Case studies in the neuropsychology of memory, East Sussex: Lawrence Erlbaum, 1997. pp. 83-110, [21]. Lambon Ralph MA, Howard D. Gogi aphasia or semantic dementia? Simulating and assessing poor verbal comprehension in a case of progressive fluent aphasia. Cognitive Neuropsychology, (in-press).This study employed sound recognition and semantic association tasks to investigate the nature of the verbal and non-verbal comprehension deficit in 10 patients with semantic dementia. The patients were impaired on both verbal and non-verbal conditions of the assessments, and their accuracy on these tasks was directly related to their scores on a range of other tests requiring access to semantic memory. Further analyses revealed that performance was graded by concept and sound familiarity and, in addition, identified significant item consistency across the different conditions of the tasks. These results support the notion that the patients' deficits across all modalities were due to degradation within a single, central network of conceptual knowledge. There were also reliable differences between conditions. The sound-picture matching task proved to be more sensitive to semantic impairment than the word-picture matching equivalent, and the patients performed significantly better on the picture than word version of a semantic association test. We propose that these differences arise directly from the nature of the mapping between input modality and semantic memory. Words and sounds have an arbitrary relationship with meaning while pictures benefit from a degree of systematicity with conceptual knowledge about the object. (C) 2000 Elsevier Science Ltd. All rights reserved.