Functional brain imaging and aging in schizophrenia
Functional brain imaging and aging in schizophrenia
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DOI：
10.1016/s0920-9964(97)00076-5
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发表时间：
1997-10-30
影响因子：
4.5
通讯作者：
Hazlett, EA
中科院分区：
文献类型：
--
作者：
Buchsbaum, MS;Hazlett, EA
精神分裂症患者，即使在病程早期，他们的脑成像结果也显示出与年龄较大的正常对照组的一些相似之处；例如，脑室增大和额叶皮质功能活动减弱。这些发现表明，正常的衰老过程和精神分裂症之间可能有相似之处，或者一些精神分裂症患者可能存在过早影响大脑的进行性过程，其方式类似于正常衰老。与其他大脑区域相比，精神分裂症患者的基底节可能会随着时间的推移表现出非典型的体积和代谢变化模式，这可能是由于抗精神病药物治疗的效果所致。然而，在我们的样本中，年龄和病程高度相关。由于缺乏对足够数量的初发或老年精神分裂症患者的研究，以及缺乏纵向设计的研究，对成像结果的解释受到限制。(C)1997年爱思唯尔科学公司。
Patients with schizophrenia, even early in the course of illness, show some similarities in their brain-imaging findings to those in older normal controls; for example, ventricular enlargement and diminished functional activity in the frontal cortex. These findings suggest a possible similarity between the normal aging process and schizophrenia, or the possible existence in some schizophrenic patients of progressive processes that prematurely affect the brain in ways analogous to normal aging. In contrast to other brain regions, the basal ganglia in schizophrenia may show an atypical pattern of volumetric and metabolic change over time, possibly because of the effects of neuroleptic treatment. However, age and illness duration are highly correlated in our samples. Interpretation of imaging results is limited by the lack of studies in an adequate number of either first-break or older schizophrenic patients and the dearth of studies with longitudinal designs. (C) 1997 Elsevier Science B.V.