Nitric Oxide Therapy for Diabetic Wound Healing
Nitric Oxide Therapy for Diabetic Wound Healing
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DOI：
10.1002/adhm.201801210
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发表时间：
2019-06-01
影响因子：
10
通讯作者：
Schoenfisch, Mark H.
中科院分区：
文献类型：
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作者：
Malone-Povolny, Maggie J.;Maloney, Sara E.;Schoenfisch, Mark H.
一氧化氮(NO)具有调节炎症和消除细菌感染的能力，是一种潜在的创伤治疗剂。有两种广泛的策略可以利用NO用于伤口愈合：从内源性储藏库中释放NO，以及从外源性来源补充NO。这份进度报告考察了各种基于NO的方法改善伤口结局的有效性，并特别关注糖尿病相关的慢性伤口。
Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This progress report examines the efficacy of a variety of NO-based methods to improve wound outcomes, with particular attention given to diabetes-associated chronic wounds.