Clinical implication of F-18 FDG PET/CT for differentiated thyroid cancer in patients with negative diagnostic iodine-123 scan and elevated thyroglobulin
Clinical implication of F-18 FDG PET/CT for differentiated thyroid cancer in patients with negative diagnostic iodine-123 scan and elevated thyroglobulin
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DOI：
10.1016/j.ejrad.2007.12.004
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Kim, Yong-Ki
中科院分区：
文献类型：
--
作者：
Kim, Seong-Jang;Lee, Tae Hong;Kim, Yong-Ki
本研究旨在探讨F-18FDG PET/CT在血清甲状腺球蛋白(TG)升高但碘123(I-123)扫描阴性的分化型甲状腺癌(DTC)中的应用价值。方法：对20例经组织病理证实、I-123扫描阴性、血清TG水平升高的分化型甲状腺癌患者进行F-18FDG PET/CT检查。结果：20例患者中，F-18FDGPET/CT发现病变18例，敏感性为90%。18名患者中有13名患者表现出局限性的局部疾病。远处转移5例，其中肺转移4例，骨转移1例。结论：F-18FDG PET/CT适用于血清甘油三酯(TG)升高但I-123全身扫描阴性的DTC局部复发和远处转移的检测和精确定位。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
This study aims to investigate the usefulness of F-18 FDG PET/CT in differentiated thyroid cancer (DTC) with elevated serum thyroglobulin (Tg) but negative iodine-123 (I-123) scan.Methods:: Twenty patients with histopathologically proven DTC, negative diagnostic I-123 scan, and elevated serum Tg levels were prospectively submitted to F-18 FDG PET/CT evaluation. The histopathologic findings consisted of 19 papillary thyroid cancers, I follicular thyroid cancer.Results: F-18 FDG PET/CT identified lesions in 18 out of 20 patients, giving a sensitivity of 90%. Thirteen of the 18 patients revealed limited loco-regional disease. Remaining 5 patients showed distant metastases, consisting of 4 patients with lung metastases and I patient with bone metastasis. Two patients revealed negative F-18 FDG PET/CT findings.Conclusion: F-18 FDG PET/CT is suitable for the detection and precise localization of loco-regional recurrences and distant metastases of DTC in patients with elevated serum Tg but negative I-123 whole body scan. (C) 2007 Elsevier Ireland Ltd. All rights reserved.