Contact-dependent inhibition of growth in Escherichia coli
Contact-dependent inhibition of growth in Escherichia coli
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DOI：
10.1126/science.1115109
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发表时间：
2005-08-19
期刊：
影响因子：
56.9
通讯作者：
Low, DA
中科院分区：
文献类型：
--
作者：
Aoki, SK;Pamma, R;Low, DA
细菌已经发展出了相互交流和竞争有限环境资源的机制。我们发现某些大肠杆菌，包括尿路致病菌株，含有。一种使用直接细胞间接触的细菌生长抑制系统。抑制是有条件的，取决于抑制细胞的生长状态和靶细胞的皮利表达状态。一个大的细胞表面蛋白命名为接触依赖性抑制剂A（CdiA）和两个伴侣分泌家族成员CdiB的生长抑制所需的。CdiAB系统可用于调节分化的细菌群体内的特定细胞的生长。
Bacteria have developed mechanisms to communicate and compete with each other for Limited environmental resources. We found that certain Escherichia coli, including uropathogenic strains, contained. a bacterial growth-inhibition system that uses direct cell-to-cell contact. Inhibition was conditional, dependent upon the growth state of the inhibitory cell and the pili expression state of the target cell. Both a large cell-surface protein designated Contact-dependent inhibitor A (CdiA) and two-partner secretion family member CdiB were required for growth inhibition. The CdiAB system may function to regulate the growth of specific cells within a differentiated bacterial population.