Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.
Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.
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DOI：
10.1001/archpediatrics.2009.214
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发表时间：
2009-12
影响因子：
--
通讯作者：
Caspi, Avshalom
中科院分区：
文献类型：
--
作者：
Danese, Andrea;Moffitt, Terrie E.;Harrington, HonaLee;Milne, Barry J.;Polanczyk, Guilherme;Pariante, Carmine M.;Poulton, Richie;Caspi, Avshalom
通过测试不良的童年经历是否能预测压力敏感生物系统（即神经、免疫和内分泌/代谢系统）的持续异常，了解为什么暴露于不良心理社会经历的儿童患心血管疾病等年龄相关疾病的风险增加。一项具有代表性的出生队列的32年前瞻性纵向研究。新西兰。共有1037名达尼丁多学科健康与发展研究的成员。在他们生命的第一个十年里，研究人员评估了3种不良的社会心理经历：社会经济劣势、虐待和社会孤立。在32岁时，研究人员评估了3种与年龄相关的疾病风险的存在：重度抑郁症、高炎症水平（高敏c反应蛋白水平bbb3mg /L）和代谢风险生物标志物的聚类（超重、高血压、高总胆固醇、低高密度脂蛋白胆固醇、高糖化血红蛋白和低最大耗氧量水平）。暴露于不良心理社会经历的儿童抑郁、高炎症水平和代谢风险标记聚集的风险增加。经历过社会经济劣势（发病率比为1.89；95%可信区间为1.36-2.62）、虐待（1.81;1.38-2.38）或社会隔离（1.87;1.38-2.51）的儿童成年后的年龄相关疾病风险较高。儿童期不良经历对成年期年龄相关疾病风险的影响是非冗余的、累积的，且独立于既定的发育和并发风险因素的影响。暴露于不良心理社会经历的儿童有持久的情绪、免疫和代谢异常，这有助于解释他们患年龄相关疾病的风险增加。促进儿童健康的心理社会经历是预防与年龄有关疾病的必要和可能具有成本效益的目标。
To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems. A 32-year prospective longitudinal study of a representative birth cohort. New Zealand. A total of 1037 members of the Dunedin Multidisciplinary Health and Development Study. During their first decade of life, study members were assessed for exposure to 3 adverse psychosocial experiences: socioeconomic disadvantage, maltreatment, and social isolation. At age 32 years, study members were assessed for the presence of 3 age-related-disease risks: major depression, high inflammation levels (high-sensitivity C-reactive protein level >3 mg/L), and the clustering of metabolic risk biomarkers (overweight, high blood pressure, high total cholesterol, low high-density lipoprotein cholesterol, high glycated hemoglobin, and low maximum oxygen consumption levels. Children exposed to adverse psychosocial experiences were at elevated risk of depression, high inflammation levels, and clustering of metabolic risk markers. Children who had experienced socioeconomic disadvantage (incidence rate ratio, 1.89; 95% confidence interval, 1.36–2.62), maltreatment (1.81; 1.38–2.38), or social isolation (1.87; 1.38–2.51) had elevated age-related-disease risks in adulthood. The effects of adverse childhood experiences on age-related-disease risks in adulthood were nonredundant, cumulative, and independent of the influence of established developmental and concurrent risk factors. Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease. The promotion of healthy psychosocial experiences for children is a necessary and potentially cost-effective target for the prevention of age-related disease.
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影响因子：
120.7
作者：
Carnethon, MR;Gulati, M;Greenland, P
通讯作者：
Greenland, P
影响因子：
120.7
作者：
ADLER, NE;BOYCE, WT;SYME, SL
通讯作者：
SYME, SL
影响因子：
158.5
作者：
Baker, Jennifer L.;Olsen, Lina W.;Sorensen, Thorkild I. A.
通讯作者：
Sorensen, Thorkild I. A.
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R
影响因子：
120.7
作者：
Costello, EJ;Compton, SN;Angold, A
通讯作者：
Angold, A