Chronic post-encephalitic epilepsy following Japanese encephalitis: Clinical features, neuroimaging data, and outcomes
Chronic post-encephalitic epilepsy following Japanese encephalitis: Clinical features, neuroimaging data, and outcomes
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日本脑炎后的慢性脑炎后癫痫：临床特征、神经影像数据和结果
DOI：
10.1016/j.seizure.2019.09.010
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发表时间：
2019-11
影响因子：
3
通讯作者：
Zhou Dong
中科院分区：
文献类型：
--
作者：
Xiong Weixi;Lu Lu;Chen Jiani;Xiao Yingfeng;Zhou Dong
PurposeJapanese encephalitis (JE), the main cause of viral encephalitis in Asia, usually presents with acute symptomatic seizures; however, there have been very few systematic reports regarding late unprovoked seizures and epilepsy. We aimed to describe the clinical features and outcomes of post-encephalitic epilepsy following JE.MethodsPatients with epilepsy with a previous confirmed diagnosis of JE visiting West China Hospital from 2013 to 2019 were enrolled in the observational case-controlled study. Patients with epilepsy with a history of other non-specific viral encephalitis were enrolled as controls. For all enrolled subjects, disease related information was recorded.ResultsForty-eight patients with JE (20 males; median age, 21.0 years; average epilepsy duration, 8.55 years) were identified. The median duration from JE to the first unprovoked seizure was 7.73 years, which significantly differed from that of the controls (7.73 vs. 2.69 years, respectively; p = 4.59 × 10−6). Most patients had focal epilepsy, and 29 (78.38%) were drug resistant. Among 45 patients with available neuroimaging data, three in fourth had no obvious abnormality, and the temporal lobe and hippocampus (22.22%) were the most affected brain regions. Six patients had surgery, and three achieved class-one seizure-free status.ConclusionThe latency to the first unprovoked seizure was longer in patients with JE than controls. Regarding chronic epilepsy, three in four had structural abnormalities, and the long-term outcomes of post-encephalitic epilepsy following JE were poor. Surgery remains an option for drug-resistant epilepsy.
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影响因子：
2.4
作者：
J. Lee;B. I. Lee;S. C. Park;W. J. Kim;J. Kim;S. A. Park;K. Huh
通讯作者：
J. Lee;B. I. Lee;S. C. Park;W. J. Kim;J. Kim;S. A. Park;K. Huh
影响因子：
5.6
作者：
H. Wieser;W. Blume;D. Fish;E. Goldensohn;A. Hufnagel;D. King;M. Sperling;H. Lüders;T. Pedley
通讯作者：
H. Wieser;W. Blume;D. Fish;E. Goldensohn;A. Hufnagel;D. King;M. Sperling;H. Lüders;T. Pedley
影响因子：
6
作者：
Sarkari, N. B. S.;Thacker, A. K.;Sarkari, M.
通讯作者：
Sarkari, M.
影响因子：
9.9
作者：
MARKS, DA;KIM, J;SPENCER, SS
通讯作者：
SPENCER, SS
影响因子：
2.2
作者：
Lancman, ME;Morris, HH
通讯作者：
Morris, HH