Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients.
Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients.
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DOI：
10.3892/or.2013.2857
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发表时间：
2014
期刊：
影响因子：
4.2
通讯作者：
N. Tada;N. Tsuno;K. Kawai;K. Murono;Takako Nirei;S. Ishihara;E. Sunami;J. Kitayama;Toshiaki Watanabe
中科院分区：
文献类型：
--
作者：
N. Tada;N. Tsuno;K. Kawai;K. Murono;Takako Nirei;S. Ishihara;E. Sunami;J. Kitayama;Toshiaki Watanabe
在本研究中，我们的目的是描述细胞因子/趋化因子在接受放化疗（CRT）的直肠癌（RC）患者中的预测价值。从35例晚期RC患者中采集CRT前后的血液样本，这些患者接受新辅助CRT，随后接受手术，并分析血浆细胞因子/趋化因子水平与CRT反应之间的相关性。CRT前sCD 40配体（sCD 40 L）水平和CRT后趋化因子配体-5（CCL-5）水平与肿瘤浸润深度和静脉浸润显著相关。此外，sCD 40 L和CCL-5以及血小板计数的显著降低与CRT的良好反应相关。在反应良好的患者中观察到CRT前血小板计数和sCD 40 L之间的显著相关性。相比之下，CRT后较高的白细胞介素（IL）-6与不良反应相关。通过各种细胞因子/趋化因子交联的血小板、免疫系统和癌细胞似乎在CRT的反应中起重要作用，并且通过了解它们的作用，可以提出改进治疗的新方法。
In the present study, we aimed to characterize the predictive value of cytokines/chemokines in rectal cancer (RC) patients receiving chemoradiation therapy (CRT). Blood samples were obtained pre- and post-CRT from 35 patients with advanced RC, who received neoadjuvant CRT followed by surgery, and the correlation between plasma levels of cytokines/chemokines and the response to CRT was analyzed. The pre-CRT levels of soluble CD40-ligand (sCD40L) and the post-CRT levels of chemokine ligand-5 (CCL-5) were significantly associated with the depth of tumor invasion and with venous invasion. In addition, a significant decrease in sCD40L and CCL-5, as well as in platelet counts, was associated with a favorable response to CRT. A significant correlation between pre-CRT platelet counts and sCD40L was observed in patients with a favorable response. By contrast, higher post-CRT interleukin (IL)-6 was associated with a poor response. Platelets, immune system and cancer cells, cross-linked through various cytokines/chemokines, appear to play an important role in the response to CRT, and by understanding their roles, new approaches for the improvement of the therapy might be proposed.