Analysis of baroreflex sensitivity during undulation pump ventricular assist device support.
Analysis of baroreflex sensitivity during undulation pump ventricular assist device support.
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DOI：
10.1111/j.1525-1594.2009.00738.x
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发表时间：
2009-07
影响因子：
2.4
通讯作者：
Hongjian Liu;Y. Shiraishi;Xiumin Zhang;Hojin Song;Y. Saijo;A. Baba;T. Yambe;Y. Abe;K. Imachi
中科院分区：
文献类型：
--
作者：
Hongjian Liu;Y. Shiraishi;Xiumin Zhang;Hojin Song;Y. Saijo;A. Baba;T. Yambe;Y. Abe;K. Imachi
本研究的目的是检查长期植入波动泵心室辅助装置 (UPVAD) 的山羊的压力反射敏感性 (BRS)，其中涉及自主神经系统。 UPVAD 涉及通过特殊连接机构连接的圆盘将无刷直流电机的旋转转换为波动运动，并在流出套管中安装水母阀以防止舒张期回流。通过左胸廓切开术将泵植入山羊的胸腔，并将流入和流出插管分别缝合到左心室心尖和降主动脉。驱动电缆经皮连接至外部控制器。以1kHz的采样频率记录心电图和血流动力学波形。清醒时，通过 R-R 间期与平均动脉压变化的线性回归斜率确定 BRS，平均动脉压变化是由盐酸甲氧明给药引起的，无论是连续驱动 UPVAD 还是在没有辅助的情况下。 UPVAD 支持期间和无帮助期间的 BRS 值分别为 1.60 +/- 0.30 毫秒/毫米汞柱和 0.98 +/- 0.22 毫秒/毫米汞柱 (n = 5，P < 0.05)。左心室辅助期间 BRS 显着改善。因此，UPVAD 支持可能会降低交感神经活动并增加副交感神经活动，以改善微循环和器官功能。
The aim of this study was to examine the baroreflex sensitivity (BRS), which involves the autonomic nervous system, in a goat with a chronically implanted undulation pump ventricular assist device (UPVAD). The UPVAD involved transforming the rotation of a brushless DC motor into an undulating motion by a disc attached via a special linking mechanism, and a jellyfish valve in the outflow cannula to prevent diastolic backflow. The pump was implanted into the thoracic cavity of a goat by a left thoracotomy, and the inflow and outflow cannulae were sutured to the apex of the left ventricle and to the descending aorta, respectively. The driving cable was wired percutaneously to an external controller. Electrocardiogram and hemodynamic waveforms were recorded at a sampling frequency of 1 kHz. BRS was determined when awake by the slope of the linear regression of R-R interval against mean arterial pressure changes, which were induced by the administration of methoxamine hydrochloride, both with continuous driving of the UPVAD as well as without assistance. BRS values during the UPVAD support and without assistance were 1.60 +/- 0.30 msec/mm Hg and 0.98 +/- 0.22 msec/mm Hg (n = 5, P < 0.05), respectively. BRS was significantly improved during left ventricular assistance. Therefore, UPVAD support might decrease sympathetic nerve activity and increase parasympathetic nerve activity to improve both microcirculation and organ function.