Tumor Engineering: The Other Face of Tissue Engineering
Tumor Engineering: The Other Face of Tissue Engineering
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DOI：
10.1089/ten.tea.2010.0135
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发表时间：
2010-07-01
影响因子：
4.1
通讯作者：
Bissell, Mina J.
中科院分区：
文献类型：
--
作者：
Ghajar, Cyrus M.;Bissell, Mina J.
多年来，组织工程的进展已经完成，通过采用仿生策略为细胞提供其原始微环境的各个方面，以重建给定组织的形式和功能单元。我们认为癌症最关键的标志是结构和功能的整合丧失；因此，类似的策略可以用来理解肿瘤生物学是理所当然的。在这篇评论中，我们讨论了Fischbach-Teschl及其同事在“肿瘤工程”背景下为本期《组织工程》特刊所做的工作，即构建复杂的细胞培养模型，概括体内肿瘤微环境的各个方面，以研究肿瘤发展、进展和多尺度治疗的动力学。我们提供了一些基本问题的例子，这些问题可以通过开发这样的模型来回答，并鼓励物理科学家和生命科学家之间的持续合作，不仅是为了再生目的，而且也是为了揭示肿瘤微环境的复杂性。
Advances in tissue engineering have been accomplished for years by employing biomimetic strategies to provide cells with aspects of their original microenvironment necessary to reconstitute a unit of both form and function for a given tissue. We believe that the most critical hallmark of cancer is loss of integration of architecture and function; thus, it stands to reason that similar strategies could be employed to understand tumor biology. In this commentary, we discuss work contributed by Fischbach-Teschl and colleagues to this special issue of Tissue Engineering in the context of 'tumor engineering', that is, the construction of complex cell culture models that recapitulate aspects of the in vivo tumor microenvironment to study the dynamics of tumor development, progression, and therapy on multiple scales. We provide examples of fundamental questions that could be answered by developing such models, and encourage the continued collaboration between physical scientists and life scientists not only for regenerative purposes, but also to unravel the complexity that is the tumor microenvironment.