Bioengineering Aspects of the Lung
Bioengineering Aspects of the Lung
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DOI：
10.7326/0003-4819-88-3-445_2
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
H. Reynolds
中科院分区：
文献类型：
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作者：
H. Reynolds
几种先天性代谢缺陷中的酶活性，以及底物对酶活性的调节。这是唯一的主要，大型纲要，这一广度的数据有关尿素循环酶。它包含了许多原始的实验数据。在每个演示文稿结束时的讨论阐明了一些重要的争议，从机制底物调节的临床调查和治疗先天性缺陷的尿素循环功能。这本书将是有用的基础科学家感兴趣的调节尿素循环酶和临床医生和临床研究人员处理患者的高氨血症综合征，特别是那些导致尿素循环酶病。这本书对烧伤的主题论述得相当透彻。在16章中，它从七个基本角度分析了烧伤问题：对组织的物理影响，分类，细菌学，治疗，愈合，心理学和进一步研究的建议。作者的丰富经验为他们全面讨论这些领域提供了背景。关于病理生理学（6）、呼吸管理（7）和研究建议（16）的章节尤其值得注意。虽然很少有参考文献的日期比1972年更近，但参考文献列表相当广泛。有几个章节使用了一个表格，通过指出文章支持或反驳某个特定假设的程度，将这些参考文献放在正确的位置。这为研究（1）烧伤降温，（2）早期切除，（3）局部用药，（4）假单胞菌疫苗提供了极好的资料来源。在每一个表格中，文章被分为人类和动物研究，根据主题的数量和对假设的支持程度。正如作者所述，“选择本书中描述的方法和结果是为了更好地理解伴随热损伤的解剖学、生理学和细菌学现象。“他们当然已经完成了这一点，并产生了一本书，这是一个很好的参考今天的烧伤临床医生。对于偶尔治疗小烧伤的医生来说，这可能太详细了，但在治疗大烧伤的所有中心都应该有。这本书是第三卷出现在一系列专题著作的“肺生物学在健康和疾病”，预计包括11卷。也许这本书的最好的一般描述是由该系列的执行编辑，克劳德Lenfant博士，在他的序言：
enzyme activities in several inborn errors of metabolism, and regulation of enzyme activity by substrates. It is the only major, large compendium of this breadth of data about the urea cycle enzymes. It contains much original experimental data. The discussions at the end of each presentation illuminate some of the important controversies from mechanisms substrate regulation to clinical investigation and therapy of inborn errors of urea cycle function. This book will be useful to basic scientists interested in regulation of urea cycle enzymes and to clinicians and clinical investigators dealing with patients with the hyperammonemia syndromes, particularly those resulting from urea cycle enzymo-pathies. This book covers the subject of burns quite thoroughly. In 16 chapters, it analyzes the burn problems from seven basic perspectives: physical effects on tissues, classification , bacteriology, treatment, healing, psychology, and suggestions for further research. The extensive experience of the authors has provided them with the background to discuss these areas comprehensively. The chapters on pathophysiol-ogy (6), respiratory management (7), and research suggestions (16) are particularly noteworthy.. Although there are few references with dates more recent than 1972, the reference list is quite extensive. Several chapters use a table to place these references in perspective by noting the degree to which the article supports or refutes a particular hypothesis. These provide an excellent source to study these areas of (1) cooling the burn, (2) early excision, (3) topical-agents, and (4) pseudomonas vaccine. In each table, artictes are divided between human and animal research, based on numbers of subjects and degree of support for the hypotheses. As the authors state, "The methods and results described in this book were selected with a view to providing a better understanding of the anatomical, physiological and bacteriological phenomena that accompany thermal injury." They have certainly accomplished this and have produced a book which is an excellent reference for today's burn clinician. It is perhaps too detailed for the physician treating the occasional small burn, but should certainly be available in all centers treating major burns. This book is the third volume to appear in a series of monographs on topics of "Lung Biology in Health and Disease" which is projected to include 11 volumes. Perhaps the best general description of the book is given by the Executive Editor of the series, Dr. Claude Lenfant, in his preface: