Intrapericardiac injections of algogenic chemicals excite primate C1-C2 spinothalamic tract neurons
Intrapericardiac injections of algogenic chemicals excite primate C1-C2 spinothalamic tract neurons
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DOI：
10.1152/ajpregu.2000.279.2.r560
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发表时间：
2000-08-01
影响因子：
2.8
通讯作者：
Foreman, RD
中科院分区：
文献类型：
--
作者：
Chandler, MJ;Zhang, JH;Foreman, RD
本实验观察了38只麻醉猕猴(Macaca Buncularis)脊髓丘脑束(STT)神经元对心包内注射致敏化学混合物(腺苷，10(-3)M；缓激肽、前列腺素E(2)、5-羟色胺、组胺，各10(-5)M)的细胞外电位的反应。化学刺激心脏/心包受体可增加21个细胞的活性，降低5个细胞的活性，但不改变12个细胞的活性。化学刺激激发的细胞接受来自伤害性机械刺激的躯体区域的输入；大多数接受区域包括颈部、下颌骨或头部区域。心包内化学物质兴奋的11个细胞的神经消融显示，致敏化学物质激活的心脏输入主要通过迷走神经传入到C1-C2节段，在11个细胞中有2个以膈或心肺交感传入为主。这些结果支持心脏迷走神经传入的激活可能导致高颈节段支配的躯体区域产生牵涉痛感的观点。
Extracellular potentials of 38 C1-C2 spinothalamic tract (STT) neurons in anesthetized monkeys (Macaca fascicularis) were examined for responses to intrapericardiac injections of an algogenic chemical mixture (adenosine, 10(-3) M; bradykinin, prostaglandin E(2), serotonin, histamine, each 10(-5) M). Chemical stimulation of cardiac/pericardiac receptors increased activity of 21 cells, decreased activity of 5 cells, and did not change activity of 12 cells. Cells excited by chemical stimuli received input from noxious mechanical stimulation of somatic fields; most receptive fields included the neck, inferior jaw, or head areas. Nerve ablations in 11 cells excited by intrapericardiac chemicals showed that cardiac input activated by algogenic chemicals traveled primarily in vagal afferent fibers to C1-C2 segments; phrenic or cardiopulmonary sympathetic inputs were predominant in 2 of 11 cells. These results supported the concept that activation of cardiac vagal afferents might lead to the production of referred pain sensation in somatic fields innervated from high cervical segments.