Steroidal glycosides from the bulbs of Ornithogalum thyrsoides
Steroidal glycosides from the bulbs of Ornithogalum thyrsoides
复制标题
DOI：
10.1021/np040108i
复制
发表时间：
2004-10-01
影响因子：
5.1
通讯作者：
Sashida, Y
中科院分区：
文献类型：
--
作者：
Kuroda, M;Mimaki, Y;Sashida, Y
对虎眼万年青新鲜鳞茎进行了植物化学分析，特别注意甾体苷成分，分离出4个新的螺甾皂苷和7个新的胆甾苷，以及3个已知的甾体化合物。新糖苷的结构是根据它们的光谱数据，包括2D NMR光谱和水解裂解的结果确定的。用HL-60人早幼粒细胞白血病细胞和HSC-2人口腔鳞状细胞癌细胞对分离的化合物进行细胞毒活性评价。
Phytochemical analyses have been carried out on the fresh bulbs of Ornithogalum thyrsoides with particular attention to the steroidal glycoside constituents, resulting in the isolation of four new spirostanol saponins and seven new cholestane glycosides, together with three known steroidal compounds. The structures of the new glycosides were determined on the basis of their spectroscopic data, including 2D NMR spectroscopy, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells.