Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan
Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan
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DOI：
10.1007/s00534-008-0015-0
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Nagakawa, Takukazu
中科院分区：
文献类型：
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作者：
Miyakawa, Shuichi;Ishihara, Shin;Nagakawa, Takukazu
2002年报告了1988年至1998年日本胆道癌统计登记处的结果。本研究对1998年至2004年登记的5，584例胆道癌患者进行了随访调查，并对2006年的随访结果进行了总结。2,732名患者的癌症部位是胆管，2,067名患者是胆囊，785名患者是乏特氏乳头。根据肿瘤浸润范围（pT）、淋巴结转移范围（pN）和分期，对这些病例进行生存分析，手术切除后的5年生存率胆管癌为33.1%，胆囊癌为41.6%，乏特氏乳头癌为52.8%。对于肝门或上级胆管癌，5年生存率随着pT、pN和f分期的增加而降低，除了pT 3与pT 4、pN 1与pN 2和III期与IVa期。中、下段胆管癌除pT 2与pT 3、pN 2与pN 3、II期与III期、III期与IVa期相比外，pT、pN、f分期越高，5年生存率越低。胆囊癌随着pT、pN、f分期的增高，5年生存率降低。对于Vater乳头癌，除了pT 1与pT 2、pN 1与pN 2、III期与IVa期外，pT、pN和f分期越高，5年生存率越低。胆囊癌的pT、pN和分期是明确的。但在胆管癌和乳头癌的某些组中无显著差异。
The results from the Japanese Biliary Tract Cancer Statistics Registry from 1988 to 1998 were reported in 2002. In the present study, we report here selectively summarized data as an overview of the 2006 follow-up survey of the registered cases from 1998 to 2004 for information bearing on problems with the treatment of cancer of the biliary tract.A total of 5,584 patients were registered from 1998 to 2004. The site of cancer was the bile duct in 2,732 patients, the gallbladder in 2,067, and the papilla of Vater in 785. Those cases were analyzed with regard to patient survival according to the extent of tumor invasion (pT), the extent of lymph node metastasis (pN) and the stage.The five-year survival rate after surgical resection was 33.1% for bile duct cancer, 41.6% for gallbladder cancer, and 52.8% for cancer of the papilla of Vater. For hilar or superior bile duct cancer, the 5-year survival rate was lower with an increase in the pT, pN and f stage, except pT3 vs. pT4, pN1 vs. pN2 and stage III vs. stage IVa. For middle or distal bile duct cancer, the 5-year survival rate was lower with increase in pT, pN and f stage, except pT2 vs. pT3, pN2 vs. pN3, stage II vs. stage III and stage III vs. stage IVa. For gallbladder cancer, the 5-year survival rate was lower with increase in pT, pN and f stage. For cancer of the papilla of Vater, the 5-year survival rate was lower with increase in pT, pN and f stage, except pT1 vs. pT2, pN1 vs. pN2, and stage III vs. stage IVa.In the present study, the outcomes of surgical treatment were better than that of the previous report from Japan and foreign countries. The pT, pN and stage of gallbladder cancer are well defined. However, there were no significant differences in some groups of those of bile duct cancer and cancer of the papilla of Vater.