AN ANIMAL-MODEL OF NEUROPATHIC PAIN - A REVIEW
AN ANIMAL-MODEL OF NEUROPATHIC PAIN - A REVIEW
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DOI：
10.1002/mus.880161007
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发表时间：
1993-10-01
期刊：
影响因子：
3.4
通讯作者：
BENNETT, GJ
中科院分区：
文献类型：
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作者：
BENNETT, GJ
最近的工作已经成功地在实验动物身上制造了疼痛的周围神经病变模型。有证据表明，动物经历异常自发疼痛和异常诱发疼痛（异常痛觉和痛觉过敏）。这些模型的实验分析已经证明了周围和中枢神经系统的潜在病理生理机制；模型神经性疼痛综合征可能是由几种不同的机制引起的。一种证据表明，由于脊髓背角抑制性中间神经元的兴奋毒性作用，这些疼痛状态逐渐集中。交感神经系统的作用似乎有所不同，这取决于神经损伤的类型和综合征的时间演变。有证据表明，伴随疼痛性周围神经病变的皮肤温度调节异常并不一定是交感血管运动传出神经活动所致。1993 John Wiley & Sons, Inc.；
Recent work has succeeded in producing models of painful peripheral neuropathies in laboratory animals. There is evidence that the animals experience both abnormal spontaneous pain and abnormal evoked pains (allodynia and hyperalgesia). Experimental analyses of these models have demonstrated potential pathophysiologic mechanisms in both the peripheral and central nervous systems; it is likely that the model neuropathic pain syndromes are due to several different mechanisms. One line of evidence suggests that these pain states gradually become centralized due to an excitotoxic effect on spinal cord dorsal horn inhibitory interneurons. The role of the sympathetic nervous system appears to vary, depending on the type of nerve injury and the temporal evolution of the syndrome. There is evidence indicating that the abnormality of cutaneous temperature regulation that often accompanies painful peripheral neuropathy is not necessarily due to the activity of sympathetic vasomotor efferents. (C) 1993 John Wiley & Sons, Inc.