Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes
Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes
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DOI：
10.1136/thx.53.1.33
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发表时间：
1998-01-01
期刊：
影响因子：
10
通讯作者：
Woodcock, A
中科院分区：
文献类型：
--
作者：
Custovic, A;Simpson, A;Woodcock, A
在英国，对猫变应原(FEL D1)的背景敏感性是哮喘的一个重要风险因素。为了调查英国家庭中猫变应原的分布、空气中FELD-1的空气动力学特性、粒度分布以及清除方法。方法收集50个养猫家庭和50个不养猫家庭的粉尘，并对50个养猫家庭和75个不养猫家庭的空气中FELD-1水平进行测量。使用Andersen采样器(每天8小时)在10个养猫家庭中测定了颗粒大小分布。在有四只猫的房子里，分别重复五天，然后在猫被从起居室区域移走后的一天、两天、四天、七天和14天。研究了高效空气颗粒物(HEPA)净化器对猫咪家庭空气中FEL-1浓度的影响。样本分别在两天内从每间房子的两个房间同时采集，其中一个房间里有猫，一天开着HEPA清洁器，另一天作为对照。在9小时内每小时收集3个样本(基线，4-5小时，结果在客厅地毯上，无猫房间的FEL-1浓度明显低于有猫房间(95%CI 167~590)，几何平均值(GM)0.9mg/g(范围0.06~33.93)比237mg/g(范围2.8~3000)；软垫家具的314倍差异(95%可信区间167至590)：1.21微克/克(范围0.06~61.9)对380微克/克(范围7.1~6000)；卧室地毯的差异228倍(95%可信区间109至478)：0.24微克/克(范围0.06~2.24)对55微克/克(范围0.06至2304)；而床垫的差异为215倍(95%可信区间101至456)：0.2微克/克(0.06-2.3)对55微克/克(0.06-3400)。在所有有猫的房子里都检测到了空气中的FEL-1水平，而且不同家庭之间的水平差异很大(范围为0.7-38 ng/m(3))。在没有养猫的75户家庭中，有22户家庭空气中的FELd-1浓度较低(范围为0.24-1.78 ng/m(3))。虽然空气中的FEL-1主要与大颗粒(9微米，约49%的过敏原回收)有关，但小颗粒(4.8微米)降至基线水平的13%。与小颗粒相关的FEL d 1水平(
Background - Sensitisation to cat allergen (Fel d 1) is an important risk factor for asthma in the UK. A study was undertaken to investigate the distribution of cat allergen in British homes, the aerodynamic characteristics and particle size distribution of airborne Fel d 1, and the method of removing it.Methods - Dust was collected from 50 homes with a cat and from 50 homes without a cat, and airborne levels of Fel d 1 were measured in 50 homes with a cat and 75 homes without a cat. Particle size distribution was determined using an Andersen sampler (8 hours/day) in 10 homes with cats. This was repeated on five separate days in a house with four cats, and then one, two, four seven, and 14 days after the cats were removed from the living room area. The effect of high efficiency particulate air (HEPA) cleaner on airborne levels of Fel d 1 was investigated in seven homes with cats. Samples were collected on two separate days from two rooms of each house concurrently, one of which contained the cat, one day with the HEPA cleaner on and the other day as a control. Three one hourly samples were collected over a nine hour period (baseline, 4-5 hours, 8-9 hours) using a high volume dust sampler (air flow rate 60 l/min) and the air sample was collected onto a microglass fibre filter (pore size 0.3 mu m).Results - Fel d 1 concentrations were much lower in houses without a cat than in those with a cat (260-fold difference (95% CI 167 to 590) in living room carpets: geometric mean (GM) 0.9 mu g/g (range 0.06-33.93) versus 237 mu g/g (range 2.8-3000); 314-fold difference (95% CI 167 to 590) in upholstered furniture: 1.21 mu g/g (range 0.06-61.9) versus 380 mu g/g (range 7.1-6000); 228-fold difference (95% CI 109 to 478) in bedroom carpets: 0.24 mu g/g (range 0.06-2.24) versus 55 mu g/g (range 0.06-2304); and 215-fold difference (95% CI 101 to 456) in mattresses: 0.2 mu g/g (range 0.06-2.3) versus 55 mu g/g (range 0.06-3400)). Airborne levels of Fel d 1 were detected in all houses with cats, and the levels varied greatly between the homes (range 0.7-38 ng/m(3)). Low concentrations of airborne Fel d 1 (range 0.24-1.78 ng/m(3)) were found in 22 of 75 homes without a cat. Although airborne Fel d 1 was mostly associated with large particles (>9 mu m, approximately 49% of the allergen recovered), small particles (4.8 mu m) which fell to 13% of their baseline level. Fel d 1 levels associated with small particles (