Physiologically relevant two-compartment pharmacokinetic models for skin.
Physiologically relevant two-compartment pharmacokinetic models for skin.
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DOI：
10.1002/1520-6017(200009)89:9
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发表时间：
2000-09
影响因子：
3.8
通讯作者：
K. D. Mccarley;A. Bunge
中科院分区：
文献类型：
--
作者：
K. D. Mccarley;A. Bunge
皮肤的药代动力学（隔室）模型已用于预测或分析化学品进入皮肤和通过皮肤的吸收。对于高度亲脂性的化学品，角质层（sc）和有活力的表皮（v.e.）两者都对化学渗透有显著的抵抗力，因此，两者都应包括在模型中。本文介绍了两室模型，分别代表sc和ve通过扩展的程序以前开发的一室模型。本文所述的双室模型是通过匹配皮肤的双膜模型的特征而开发的。这些房室模型进行了比较，与膜表示的s.c.和V.E.几种不同的皮肤接触情况。当有效时，它是许多化学品接触的情况下，使用膜模型（模型B2）的特征时间开发的双室模型更接近代表双膜模型比开发的模型与平衡条件的膜模型（模型B1）。当模型B2无效时，则推荐模型B1。提供了从各种一室或二室模型选项中进行选择的标准。
Pharmacokinetic (compartment) models for skin have been used to predict or analyze absorption of chemical into and through skin. For highly lipophilic chemicals, the stratum corneum (sc) and the viable epidermis (v.e.) both contribute a significant resistance to chemical penetration and thus, both should be included in the model. This paper describes two-compartment models that represent the sc and the ve separately by extending the procedures previously developed for one-compartment models. The two-compartment models described here were developed by matching characteristics of a two-membrane model of skin. These compartment models were compared with membrane representations of the s.c. and v.e. for several different dermal exposure scenarios. When valid, which it is for many chemical exposure scenarios, the two-compartment model developed using characteristic times of the membrane model (model B2) more closely represents the two-membrane model than the model developed with equilibrium conditions of the membrane model (model B1). When model B2 is invalid, then model B1 is recommended. Criteria are provided for choosing from the various one- or two-compartment model options.