Species and rat strain variation in pancreatic nodule induction by azaserine.
Species and rat strain variation in pancreatic nodule induction by azaserine.
复制标题
重氮丝氨酸诱导胰腺结节的物种和大鼠品系变化。
DOI：
10.1093/jnci/59.4.1273
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
D. Longnecker
中科院分区：
文献类型：
--
作者：
B. Roebuck;B. Roebuck;D. Longnecker
亚毒性剂量氮杂塞林在开始治疗后4-6个月诱导外交种Wistar大鼠、外交种W/LEW和F344大鼠以及外交种Charles River CD-1白化小鼠胰腺出现非典型腺泡细胞结节（AACN）。这些AACN明显代表癌前病变，其中一些有可能发展为腺瘤或腺癌。Wistar和W/LEW大鼠对诱导结节反应高；约90%的近交Wistar大鼠和所有W/LEW大鼠均出现AACN。F344大鼠易感程度较低，AACN发生率约为Wistar大鼠的10%。雌性大鼠产生的AACN大约是雄性大鼠的一半。这只小鼠的反应介于F344和两只Wistar大鼠之间。叙利亚金仓鼠和13号品系豚鼠相对无反应。这些氮杂塞菌素诱导AACN的研究为选择致癌性氮杂塞菌素方案提供了依据，并提示年轻雄性W/LEW大鼠是所研究动物中最敏感的。
Subtoxic doses of azaserine induced atypical acinar cell nodules (AACN) in the pancreases of outbred Wistar rats, inbred W/LEW and F344 rats, and outbred Charles River CD-1 albino mice 4-6 months after initiation of treatment in the growing animal. These AACN apparently represented preneoplastic lesions, some of which have the potential to develop into adenomas or adenocarcinomas. Wistar and W/LEW rats were highly responsive to nodule induction; AACN developed in about 90% of the outbred Wistar rats and in all of the W/LEW rats tested. F344 rats were less susceptible and developed about 10% as many AACN as the Wistar rats. Female rats developed approximately half as many AACN as males. The mouse was intermediate in response between the F344 and the two Wistar rats. Syrian golden hamsters and strain 13 guinea pigs were relatively unresponsive. These studies of azaserine-induced AACN provided a basis for selection of carcinogenic azaserine regimens and suggested that the young male W/LEW rat was the most sensitive of the animals studied.