Zinc‐induced granuloma—a unique complication of insulin therapy
Zinc‐induced granuloma—a unique complication of insulin therapy
复制标题
锌诱发的肉芽肿——胰岛素治疗的独特并发症
DOI：
10.1111/j.1365-2230.1989.tb00938.x
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发表时间：
1989
影响因子：
4.1
通讯作者：
M. Sandler
中科院分区：
文献类型：
--
作者：
H. Jordaan;M. Sandler
一位55岁的糖尿病女性，接受了短效和中效胰岛素的联合治疗，在注射部位出现了无菌呋喃样病变，最终愈合了萎缩的疤痕。组织病理学上，最初的嗜中性粒细胞阶段之后是肉芽肿和纤维化期。据认为，锌是中效胰岛素的一种成分，是皮肤反应和肉芽肿形成的原因。锌诱导的肉芽肿是胰岛素治疗的一种罕见的组织病理学并发症。
A 55‐year‐old diabetic female treated with a combination of a short‐ and intermediate‐acting insulin, developed sterile furunculoid lesions at the injection sites which eventually healed with atrophic scars. Histopathologically, an initial neutrophilic stage was followed by granulomatous and fibrotic stages. It was considered that zinc, a component of the intermediate‐acting insulin, was responsible for the cutaneous reaction and granuloma formation. Zinc‐induced granuloma is a rare histopathological complication of insulin therapy.