COMPARATIVE STUDIES ON THE ULTRASTRUCTURE OF MALIGNANT-MELANOMA IN FISH AND HUMAN BY FREEZE-ETCHING AND TRANSMISSION ELECTRON-MICROSCOPY
COMPARATIVE STUDIES ON THE ULTRASTRUCTURE OF MALIGNANT-MELANOMA IN FISH AND HUMAN BY FREEZE-ETCHING AND TRANSMISSION ELECTRON-MICROSCOPY
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DOI：
10.1007/bf00395486
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
KOLLINGER, G
中科院分区：
文献类型：
--
作者：
RIEHL, R;SCHARTL, M;KOLLINGER, G
用透射电镜和冷冻蚀刻技术研究了剑尾鱼和人的恶性黑色素瘤。在鱼类和人类的黑色素瘤中，细胞显示质膜的相互指状。核大，分叶状，有许多核孔。黑素体丰富，黑素体复合体（复合黑素体）定期出现。在鱼类和人类黑色素瘤中可以发现胞饮囊泡，显示出肿瘤中频率和分布模式的局部差异。来自鱼类和人类的MM细胞中缺乏细胞间连接。FE技术显示出相当大的优势，在展示膜表面的特点，如核孔或胞饮小泡。鱼类黑色素瘤的Fe复制品与人类的相似。鱼类和人类的黑色素瘤可能反映了相同的生物学现象。
Malignant melanomas (MM) in the fish Xiphophorus and in humans were studied both by transmission electron microscopy (TEM) and freeze-etching (FE). In both fish and human melanomas the cells show interdigitations of the plasma membranes. The nuclei are large and lobulated and have many nuclear pores. Melanosomes are abundant and melanosome complexes (compound melanosomes) occur regularly. Pinocytic vesicles could be demonstrated in fish and human melanomas showing local differences in frequency and distribution patterns in the tumor. Intercellular junctions are lacking in MM cells from fish and humans. The FE technique showed considerable advantages in demonstrating membrane-surface peculiarities such as nuclear pores or pinocytotic vesicles. The Fe replicas of fish melanomas are like those of humans. Melanoma in fish and humans may reflect the same biological phenomenon.