Field cancerization: Treatment
Field cancerization: Treatment
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DOI：
10.1016/j.jaad.2020.03.127
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发表时间：
2020-09-01
影响因子：
13.8
通讯作者：
Ruiz, Emily S.
中科院分区：
文献类型：
--
作者：
Cornejo, Christine M.;Jambusaria-Pahlajani, Anokhi;Ruiz, Emily S.
野战癌变治疗的目标是降低发生角质形成细胞癌的风险。选择合适的治疗方法取决于癌变的程度和浸润性皮肤鳞状细胞癌的数量。其他考虑因素包括治疗效果、成本、副作用和患者偏好。现场治疗是首选的，因为它们解决了临床上可见的疾病和亚临床非典型性。然而，病变导向治疗对于更难治疗的病变或需要进行组织学诊断的病变是有用的。广泛野癌变的患者受益于野定向和病变定向治疗的组合。这一继续医学教育系列的第二篇文章提供了一个框架，以指导现场癌变治疗的循证决策。
The goal of field cancerization treatment is to reduce the risk of developing keratinocyte carcinoma. Selecting the appropriate therapy depends on the degree of field cancerization and the number of invasive cutaneous squamous cell carcinomas. Other considerations include treatment efficacy, cost, side effects, and patient preference. Field therapies are preferred because they address clinically visible disease and subclinical atypia. However, lesion-directed therapies are useful for lesions that are more difficult to treat or those where a histologic diagnosis is required. Patients with extensive field cancerization benefit from a combination of field-directed and lesion-directed treatments. The second article in this continuing medical education series provides a framework to guide evidence-based decision making for field cancerization treatment.