Saturated with fat: new parspectives on lipotoxicity
Saturated with fat: new parspectives on lipotoxicity
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DOI：
10.1097/mco.0b013e32832182ee
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发表时间：
2009-03-01
影响因子：
3.1
通讯作者：
Sturley, Stephen L.
中科院分区：
文献类型：
--
作者：
Garbarino, Jeanne;Sturley, Stephen L.
综述目的：介绍细胞脂毒性事件的介质和机制及其与人类健康的关系。最近的发现脂质酰基转移酶基因从酵母中分离到小鼠和人类，这导致了一种范式的转变，即现在确定所有脂肪酸都是有毒的，尽管是在组织特定的模式和不同的机制下。此外，葡萄糖稳态失调与过量脂肪酸的结合提供了一种协同效应，导致糖脂毒性和细胞死亡。这些发现与代谢综合征发病机制相关的疾病状态的发展有关。在一个被诊断患有代谢紊乱的人数惊人的时代，我们必须了解慢性代谢过剩的后果。过量的脂肪，无论是饱和脂肪还是其他脂肪，都必须加以调节。这种内稳态的多个方面正在出现，其中一些在这里描述。
Purpose of reviewTo present current perspectives on the mediators and mechanisms of cyto-lipotoxic events and their relevance to human health.Recent findingsThe relatively recent isolation of lipid acyltransferase genes from yeast to mice and humans has resulted in a paradigm shift that now establishes all fatty acids as toxic, albeit in tissue specific patterns and by different mechanisms. Furthermore, the dysregulation of glucose homeostasis in combination with excess fatty acids provides a synergistic effect leading to glucolipotoxicity and cell death. These findings are relevant to the development of disease states associated with the pathogenesis of the metabolic syndrome.SummaryIn an era when an astounding number of people are diagnosed with metabolic disorders, it is imperative that we understand the consequences of a chronic metabolic surplus. Excessive fat, saturated or otherwise, has to be accommodated. Multiple aspects of this homeostasis are emerging, some of which are described here.