THE INCREASED SUSCEPTIBILITY OF WOMEN TO MULTIPLE-SCLEROSIS
THE INCREASED SUSCEPTIBILITY OF WOMEN TO MULTIPLE-SCLEROSIS
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DOI：
10.1017/s0317167100041664
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发表时间：
1992-11-01
影响因子：
3
通讯作者：
MASSE, C
中科院分区：
文献类型：
--
作者：
DUQUETTE, P;PLEINES, J;MASSE, C
许多具有自身免疫病因的疾病具有倾斜的性别分布。在大多数情况下，妇女比男子更容易受到影响。人口研究的回顾表明，多发性硬化症（MS）中女性的优势几乎是恒定的。我们发现，这种优势进一步增加，在早期以及迟发性病例中，在家族性病例中，以及在MS双胞胎和HLA-DR 2等位基因，这已与MS在高加索人群中，是显着更频繁的女性比男性MS。“规则”已经建立了多因素疾病：MS违反大多数这些规则。MS的性别分布偏态可归因于已知的激素和性别对免疫反应的影响以及遗传影响。
Many diseases with an auto-immune etiology have a skewed sex distribution. In the majority of instances, women are affected more frequently than men. A review of population studies demonstrates that the preponderance of women in multiple sclerosis (MS) is almost constant. We show that this preponderance is further increased in early as well as in late-onset cases, in familial cases as well as in MS twin pairs and that the HLA-DR2 allele, which has been associated with MS in Caucasian populations, is significantly more frequent in women than in men with MS. "Rules" have been established for multifactorial diseases: MS contravenes most of those rules. The skewed sex distribution in MS could be attributed to the known hormonal and gender influences on the immune response, as well as to genetic influences.