Correlation of Macular Choroidal Thickness with Concentrations of Aqueous Vascular Endothelial Growth Factor in High Myopia
Correlation of Macular Choroidal Thickness with Concentrations of Aqueous Vascular Endothelial Growth Factor in High Myopia
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DOI：
10.3109/02713683.2014.973043
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发表时间：
2015-03-01
影响因子：
2
通讯作者：
Chu, Yanhua
中科院分区：
文献类型：
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作者：
Chen, Wei;Song, Hui;Chu, Yanhua
目的：探讨高度近视患者房水和血清中血管内皮生长因子(VEGF)水平与黄斑脉络膜厚度的关系。材料与方法：采用酶联免疫吸附试验(EL ISA)检测高度近视患者(n=36眼，36例)和正常对照组(n=42眼，42例)房水和血清中血管内皮生长因子(VEGF)浓度。通过增强深度成像光学相干断层扫描(EDI-OCT)测量黄斑脉络膜厚度，即视网膜色素上皮(RPE)到巩膜界面的距离。结果：高度近视患者房水中血管内皮生长因子水平明显低于对照组(61.4±27.6pg/ml对122.6+/-52.4pg/ml；P
Purpose: To investigate the association of both aqueous and serum vascular endothelial growth factor (VEGF) levels and macular choroidal thickness in high myopia.Materials and methods: VEGF concentrations were measured in aqueous and serum samples via enzyme-linked immunosorbent assay (ELISA) and compared between high myopia (n = 36 eyes, 36 patients) and normal control (n = 42 eyes, 42 patients) eyes. Macular choroidal thickness, the distance from the retinal pigment epithelium (RPE) to the scleral interface, was determined via enhanced depth-imaging optical coherence tomography (EDI-OCT). Axial length was measured using the intraocular (IOL) lens Master.Results: Aqueous levels of VEGF from high myopia patients were significantly lower compared with those from control persons (61.4 +/- 27.6 versus 122.6 +/- 52.4 pg/ml; p